Hs01425344_cn

• Gene Symbol: PARP10
• Assay Reference Genome Location: Chr.8:143977176 on build GRCh38
• Cytoband: 8q24.3

Target Gene Details

• Entrez Gene ID: 84875
• Gene Name: poly(ADP-ribose) polymerase family member 10
• Gene Aliases: ARTD10
• Location: Chr.8:143977152-143986471 on Build GRCh38
• Assay Gene Location: Overlaps - Exon 10

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PARP10	NM_001317895.1			NP_001304824.1
	NM_032789.4			NP_116178.2
	NR_134234.1
	XM_011517336.2			XP_011515638.1
	AI470346.1
	AK027370.1			BAB55067.1
	AK075250.1			BAC11498.1
	AK124017.1
	AK128537.1
	AK129821.1
	BC014229.2			AAH14229.2
	BC019030.2			AAH19030.2
	BU625932.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv6445	Chr.8:143961415 - 143994522 on Build GRCh38	Insertion	PARP10 PLEC GRINA
nsv470249	Chr.8:143889098 - 144519234 on Build GRCh38	Loss	SMPD5 SLC39A4 HSF1 ADCK5 MIR661 LRRC14 SHARPIN CYC1 MIR6848 MIR6847 FOXH1 SCX GPT KIFC2 FBXL6 MAF1 MIR6893 TONSL MIR1234 GPAA1 PPP1R16A EXOSC4 TONSL-AS1 MROH1 MFSD3 CYHR1 MIR939 TMEM249 WDR97 PLEC OPLAH RECQL4 PARP10 BOP1 SPATC1 DGAT1 VPS28 MIR6849 SLC52A2 LOC101928953 LOC101928902 CPSF1 MIR7112 SCRT1 MIR6846 HGH1 GRINA
nsv515809	Chr.8:143904439 - 144519234 on Build GRCh38	Gain+Loss	SMPD5 SLC39A4 HSF1 ADCK5 MIR661 LRRC14 SHARPIN CYC1 MIR6848 MIR6847 FOXH1 SCX GPT KIFC2 FBXL6 MAF1 MIR6893 TONSL MIR1234 GPAA1 PPP1R16A EXOSC4 TONSL-AS1 MROH1 MFSD3 CYHR1 MIR939 TMEM249 WDR97 PLEC OPLAH RECQL4 PARP10 BOP1 SPATC1 DGAT1 VPS28 MIR6849 SLC52A2 LOC101928953 LOC101928902 CPSF1 MIR7112 SCRT1 MIR6846 HGH1 GRINA
nsv612914	Chr.8:143972494 - 144120626 on Build GRCh38	Loss	SMPD5 WDR97 SHARPIN PLEC CYC1 OPLAH MIR6847 PARP10 SPATC1 MAF1 MIR6846 GPAA1 EXOSC4 GRINA
dgv12431n54	Chr.8:143845100 - 144161320 on Build GRCh38	Loss	MROH1 SMPD5 MIR661 WDR97 SHARPIN PLEC CYC1 OPLAH MIR6847 EPPK1 PARP10 SPATC1 MAF1 MIR6846 GPAA1 EXOSC4 HGH1 GRINA
nsv950015	Chr.8:143866633 - 144125597 on Build GRCh38	Deletion	SMPD5 MIR661 WDR97 SHARPIN PLEC CYC1 OPLAH MIR6847 EPPK1 PARP10 SPATC1 MAF1 MIR6846 GPAA1 EXOSC4 GRINA
nsv1161815	Chr.8:143775169 - 144080674 on Build GRCh38	Deletion	LOC642574 SMPD5 MIR661 NRBP2 PLEC OPLAH MIR6847 MIR937 SCRIB EPPK1 PARP10 SPATC1 PUF60 MIR6845 MIR6846 EXOSC4 GRINA
nsv470250	Chr.8:143917934 - 144097007 on Build GRCh38	Gain	PARP10 SMPD5 SPATC1 MIR661 PLEC CYC1 OPLAH MIR6847 MIR6846 GPAA1 EXOSC4 GRINA
dgv12433n54	Chr.8:143902404 - 144120626 on Build GRCh38	Gain	SMPD5 MIR661 WDR97 SHARPIN PLEC CYC1 OPLAH MIR6847 PARP10 SPATC1 MAF1 MIR6846 GPAA1 EXOSC4 GRINA
nsv612906	Chr.8:143917935 - 144090784 on Build GRCh38	Loss	PARP10 SMPD5 SPATC1 MIR661 PLEC OPLAH MIR6847 MIR6846 GPAA1 EXOSC4 GRINA

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

protein ADP-ribosylation
negative regulation of gene expression
regulation of chromatin assembly
negative regulation of NF-kappaB transcription factor activity
negative regulation of protein import into nucleus, translocation
negative regulation of viral genome replication
negative regulation of fibroblast proliferation
protein poly-ADP-ribosylation
protein auto-ADP-ribosylation
negative regulation of protein K63-linked ubiquitination

Function(s)

NAD+ ADP-ribosyltransferase activity
protein binding
K63-linked polyubiquitin binding