Hs01434049_cn

• Gene Symbol: E2F4
• Assay Reference Genome Location: Chr.16:67197889 on build GRCh38
• Cytoband: 16q22.1

Target Gene Details

• Entrez Gene ID: 1874
• Gene Name: E2F transcription factor 4
• Gene Aliases: E2F-4
• Location: Chr.16:67192165-67198918 on Build GRCh38
• Assay Gene Location: Overlaps Intron 8 - Intron 9

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
E2F4	NM_001950.3			NP_001941.2
	AB451292.1
	AB451425.1
	BC033180.1			AAH33180.1
	S75174.1			AAB32597.1
	U15641.1			AAC50119.1
	X86096.1			CAA60050.2

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv522852	Chr.16:67153308 - 68071571 on Build GRCh38	Gain	LOC107984813 E2F4 AGRP CTRL DPEP2 LCAT ACD ATP6V0D1 PARD6A PSMB10 CTCF RANBP10 LOC100131303 FBXL8 LRRC36 DDX28 DPEP3 NOL3 KCTD19 NRN1L TSNAXIP1 LOC105369155 HSF4 PLEKHG4 GFOD2 THAP11 HSD11B2 CENPT FHOD1 TRADD PSKH1 C16orf86 DUS2 ELMO3 ZDHHC1 LOC100505942 EDC4 NUTF2 LRRC29 TPPP3 FAM65A TMEM208 SLC12A4 EXOC3L1 CARMIL2 KIAA0895L ENKD1 MIR328 SLC9A5
nsv827707	Chr.16:67148355 - 67289296 on Build GRCh38	Loss	LOC105369155 C16orf70 B3GNT9 HSF4 E2F4 PLEKHG4 FBXL8 FHOD1 LRRC29 TMEM208 TRADD EXOC3L1 KIAA0895L ELMO3 NOL3 MIR328 SLC9A5
nsv952044	Chr.16:67141198 - 67244397 on Build GRCh38	Deletion	LOC105369155 C16orf70 B3GNT9 HSF4 E2F4 FBXL8 FHOD1 LRRC29 TMEM208 TRADD EXOC3L1 KIAA0895L ELMO3 NOL3 MIR328
nsv1160429	Chr.16:67161549 - 67220197 on Build GRCh38	Deletion	EXOC3L1 LOC105369155 HSF4 E2F4 KIAA0895L ELMO3 FBXL8 LRRC29 NOL3 MIR328
nsv457513	Chr.16:67181417 - 67282697 on Build GRCh38	Loss	EXOC3L1 LOC105369155 E2F4 KIAA0895L PLEKHG4 ELMO3 FHOD1 LRRC29 MIR328 TMEM208 SLC9A5
nsv524492	Chr.16:67174030 - 67294550 on Build GRCh38	Loss	LOC105369155 E2F4 PLEKHG4 FHOD1 LRRC29 TMEM208 EXOC3L1 KIAA0895L ELMO3 NOL3 MIR328 KCTD19 SLC9A5
nsv524363	Chr.16:67136529 - 68071571 on Build GRCh38	Loss	C16orf70 LOC107984813 B3GNT9 E2F4 AGRP CTRL DPEP2 LCAT ACD ATP6V0D1 PARD6A PSMB10 CTCF RANBP10 LOC100131303 FBXL8 LRRC36 DDX28 DPEP3 NOL3 KCTD19 NRN1L TSNAXIP1 LOC105369155 HSF4 PLEKHG4 GFOD2 THAP11 HSD11B2 CENPT FHOD1 TRADD PSKH1 C16orf86 DUS2 ELMO3 ZDHHC1 LOC100505942 EDC4 NUTF2 LRRC29 TPPP3 FAM65A TMEM208 SLC12A4 EXOC3L1 CARMIL2 KIAA0895L ENKD1 MIR328 SLC9A5

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

RNA metabolism protein, nucleic acid metabolism protein, general transcription factor

Gene Ontology Categories:

Process(es)

regulation of transcription involved in G1/S transition of mitotic cell cycle
epithelial cell development
transcription from RNA polymerase II promoter
cell volume homeostasis
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
blood circulation
organ morphogenesis
regulation of cell proliferation
motile cilium assembly
positive regulation of transcription from RNA polymerase II promoter
centriole assembly
multi-ciliated epithelial cell differentiation

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
protein domain specific binding
promoter-specific chromatin binding