Hs01458689_cn

• Gene Symbol: E2F4
• Assay Reference Genome Location: Chr.16:67195793 on build GRCh38
• Cytoband: 16q22.1

Target Gene Details

• Entrez Gene ID: 1874
• Gene Name: E2F transcription factor 4
• Gene Aliases: E2F-4
• Location: Chr.16:67192165-67198918 on Build GRCh38
• Assay Gene Location: Overlaps Intron 6 - Exon 7

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
E2F4	NM_001950.3			NP_001941.2
	AB451292.1
	AB451425.1
	BC033180.1			AAH33180.1
	S75174.1			AAB32597.1
	U15641.1			AAC50119.1
	X86096.1			CAA60050.2

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv522852	Chr.16:67153308 - 68071571 on Build GRCh38	Gain	NRN1L CTCF PSMB10 PARD6A SLC9A5 CENPT LCAT EDC4 LOC105369155 E2F4 LOC100505942 RANBP10 PSKH1 TPPP3 C16orf86 DPEP2 MIR328 NOL3 CARMIL2 TSNAXIP1 PLEKHG4 LOC100131303 HSF4 ELMO3 EXOC3L1 LOC107984813 LRRC36 ATP6V0D1 GFOD2 DDX28 FHOD1 THAP11 ENKD1 TRADD CTRL DPEP3 SLC12A4 FAM65A TMEM208 KCTD19 DUS2 HSD11B2 AGRP KIAA0895L ACD NUTF2 FBXL8 ZDHHC1 LRRC29
nsv827707	Chr.16:67148355 - 67289296 on Build GRCh38	Loss	LOC105369155 PLEKHG4 TMEM208 E2F4 C16orf70 HSF4 KIAA0895L ELMO3 EXOC3L1 SLC9A5 FHOD1 FBXL8 MIR328 NOL3 TRADD LRRC29 B3GNT9
nsv952044	Chr.16:67141198 - 67244397 on Build GRCh38	Deletion	LOC105369155 TMEM208 E2F4 C16orf70 HSF4 KIAA0895L ELMO3 EXOC3L1 FHOD1 FBXL8 MIR328 NOL3 TRADD LRRC29 B3GNT9
nsv1160429	Chr.16:67161549 - 67220197 on Build GRCh38	Deletion	LOC105369155 E2F4 FBXL8 HSF4 MIR328 NOL3 KIAA0895L ELMO3 EXOC3L1 LRRC29
nsv457513	Chr.16:67181417 - 67282697 on Build GRCh38	Loss	SLC9A5 FHOD1 LOC105369155 PLEKHG4 TMEM208 E2F4 MIR328 KIAA0895L ELMO3 EXOC3L1 LRRC29
nsv524492	Chr.16:67174030 - 67294550 on Build GRCh38	Loss	LOC105369155 PLEKHG4 TMEM208 E2F4 KCTD19 KIAA0895L ELMO3 EXOC3L1 SLC9A5 FHOD1 MIR328 NOL3 LRRC29
nsv524363	Chr.16:67136529 - 68071571 on Build GRCh38	Loss	NRN1L CTCF PSMB10 PARD6A SLC9A5 CENPT LCAT EDC4 LOC105369155 E2F4 LOC100505942 C16orf70 RANBP10 PSKH1 TPPP3 C16orf86 DPEP2 MIR328 NOL3 CARMIL2 TSNAXIP1 PLEKHG4 LOC100131303 HSF4 ELMO3 EXOC3L1 LOC107984813 LRRC36 ATP6V0D1 GFOD2 DDX28 FHOD1 THAP11 ENKD1 TRADD B3GNT9 CTRL DPEP3 SLC12A4 FAM65A TMEM208 KCTD19 DUS2 HSD11B2 AGRP KIAA0895L ACD NUTF2 FBXL8 ZDHHC1 LRRC29

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

RNA metabolism protein, nucleic acid metabolism protein, general transcription factor

Gene Ontology Categories:

Process(es)

regulation of transcription involved in G1/S transition of mitotic cell cycle
epithelial cell development
transcription from RNA polymerase II promoter
cell volume homeostasis
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
blood circulation
organ morphogenesis
regulation of cell proliferation
motile cilium assembly
positive regulation of transcription from RNA polymerase II promoter
centriole assembly
multi-ciliated epithelial cell differentiation

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
protein domain specific binding
promoter-specific chromatin binding