Hs01566541_cn

• Gene Symbol: E2F4
• Assay Reference Genome Location: Chr.16:67192367 on build GRCh38
• Cytoband: 16q22.1

Target Gene Details

• Entrez Gene ID: 1874
• Gene Name: E2F transcription factor 4
• Gene Aliases: E2F-4
• Location: Chr.16:67192165-67198918 on Build GRCh38
• Assay Gene Location: Overlaps Exon 1 - Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
E2F4	NM_001950.3			NP_001941.2
	AB451292.1
	AB451425.1
	BC033180.1			AAH33180.1
	S75174.1			AAB32597.1
	U15641.1			AAC50119.1
	X86096.1			CAA60050.2

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv522852	Chr.16:67153308 - 68071571 on Build GRCh38	Gain	DPEP2 LOC100505942 NOL3 LCAT EXOC3L1 LRRC29 SLC12A4 PSKH1 NRN1L CENPT HSF4 E2F4 PARD6A DUS2 LOC107984813 RANBP10 CTCF ATP6V0D1 EDC4 AGRP ELMO3 TPPP3 PLEKHG4 FHOD1 DDX28 TSNAXIP1 ACD NUTF2 GFOD2 LOC100131303 DPEP3 LRRC36 ENKD1 FAM65A SLC9A5 MIR328 ZDHHC1 LOC105369155 HSD11B2 CTRL C16orf86 TRADD KCTD19 TMEM208 FBXL8 THAP11 KIAA0895L CARMIL2 PSMB10
nsv827707	Chr.16:67148355 - 67289296 on Build GRCh38	Loss	LOC105369155 C16orf70 NOL3 B3GNT9 EXOC3L1 LRRC29 TRADD ELMO3 TMEM208 FBXL8 HSF4 E2F4 PLEKHG4 KIAA0895L FHOD1 SLC9A5 MIR328
nsv952044	Chr.16:67141198 - 67244397 on Build GRCh38	Deletion	LOC105369155 C16orf70 NOL3 B3GNT9 EXOC3L1 LRRC29 TRADD ELMO3 TMEM208 FBXL8 HSF4 E2F4 KIAA0895L FHOD1 MIR328
nsv1160429	Chr.16:67161549 - 67220197 on Build GRCh38	Deletion	FBXL8 LOC105369155 HSF4 E2F4 NOL3 KIAA0895L EXOC3L1 LRRC29 MIR328 ELMO3
nsv457513	Chr.16:67181417 - 67282697 on Build GRCh38	Loss	LOC105369155 E2F4 PLEKHG4 KIAA0895L EXOC3L1 FHOD1 LRRC29 SLC9A5 MIR328 ELMO3 TMEM208
nsv524492	Chr.16:67174030 - 67294550 on Build GRCh38	Loss	LOC105369155 NOL3 EXOC3L1 LRRC29 ELMO3 KCTD19 TMEM208 E2F4 PLEKHG4 KIAA0895L FHOD1 SLC9A5 MIR328
nsv524363	Chr.16:67136529 - 68071571 on Build GRCh38	Loss	DPEP2 LOC100505942 C16orf70 NOL3 LCAT EXOC3L1 LRRC29 SLC12A4 PSKH1 NRN1L CENPT HSF4 E2F4 PARD6A DUS2 LOC107984813 RANBP10 CTCF B3GNT9 ATP6V0D1 EDC4 AGRP ELMO3 TPPP3 PLEKHG4 FHOD1 DDX28 TSNAXIP1 ACD NUTF2 GFOD2 LOC100131303 DPEP3 LRRC36 ENKD1 FAM65A SLC9A5 MIR328 ZDHHC1 LOC105369155 HSD11B2 CTRL C16orf86 TRADD KCTD19 TMEM208 FBXL8 THAP11 KIAA0895L CARMIL2 PSMB10

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

RNA metabolism protein, nucleic acid metabolism protein, general transcription factor

Gene Ontology Categories:

Process(es)

regulation of transcription involved in G1/S transition of mitotic cell cycle
epithelial cell development
transcription from RNA polymerase II promoter
cell volume homeostasis
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
blood circulation
organ morphogenesis
regulation of cell proliferation
motile cilium assembly
positive regulation of transcription from RNA polymerase II promoter
centriole assembly
multi-ciliated epithelial cell differentiation

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
protein domain specific binding
promoter-specific chromatin binding