Hs01600752_cn

• Gene Symbol: REST
• Assay Reference Genome Location: Chr.4:56908171 on build GRCh38
• Cytoband: 4q12

Target Gene Details

• Entrez Gene ID: 5978
• Gene Name: RE1 silencing transcription factor
• Gene Aliases: NRSF, WT6, XBR
• Location: Chr.4:56907876-56935847 on Build GRCh38
• Assay Gene Location: Overlaps Exon 1 - Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
REST	NM_005612.4			NP_005603.3
	XM_017008527.1			XP_016864016.1
	BC038985.1			AAH38985.1
	BC132859.1
	BC136491.1
	JX896957.1
	JX896958.1
	JX896959.1
	JX896960.1
	JX896961.1
	JX896962.1
	JX896963.1
	JX896964.1
	JX896965.1
	JX896971.1
	JX896972.1
	JX896973.1
	JX896974.1
	JX896975.1
	JX896976.1
	JX896977.1
	JX896978.1
	JX896979.1
	JX896980.1
	JX896983.1
	JX896984.1
	JX896985.1
	JX896986.1
	JX896987.1
	JX896988.1
	JX896991.1
	KC117266.1
	U13879.1			AAC50115.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv5214n100	Chr.4:56786612 - 56999637 on Build GRCh38	Gain	NOA1 REST POLR2B SPINK2
nsv594205	Chr.4:56907276 - 56908898 on Build GRCh38	Gain	REST
nsv822562	Chr.4:56902489 - 56913549 on Build GRCh38	Gain	REST
nsv1074717	Chr.4:56905133 - 56910334 on Build GRCh38	Deletion	REST
esv22393	Chr.4:56906104 - 56909418 on Build GRCh38	Loss	REST
nsv594206	Chr.4:56907429 - 56909377 on Build GRCh38	Loss	REST

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

C2H2 zinc finger transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
hematopoietic progenitor cell differentiation
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
negative regulation of cell proliferation
negative regulation of gene expression
negative regulation of aldosterone biosynthetic process
cellular response to drug
positive regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation by host of viral transcription
negative regulation of neuron differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of calcium ion-dependent exocytosis
negative regulation of insulin secretion
negative regulation of neurogenesis
cardiac muscle cell myoblast differentiation
histone H4 deacetylation
cellular response to electrical stimulus
cellular response to glucocorticoid stimulus
potassium ion transmembrane transport
negative regulation of cortisol biosynthetic process
negative regulation of dense core granule biogenesis
negative regulation of mesenchymal stem cell differentiation
negative regulation of amniotic stem cell differentiation

Function(s)

core promoter sequence-specific DNA binding
core promoter binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
histone deacetylase activity
protein binding
transcription factor binding
outward rectifier potassium channel activity
protein complex binding
transcription regulatory region DNA binding
metal ion binding