Hs01605230_cn

• Gene Symbol: PDGFA
• Assay Reference Genome Location: Chr.7:518998 on build GRCh38
• Cytoband: 7p22.3

Target Gene Details

• Entrez Gene ID: 5154
• Gene Name: platelet derived growth factor subunit A
• Gene Aliases: PDGF-A, PDGF1
• Location: Chr.7:497245-520668 on Build GRCh38
• Assay Gene Location: Overlaps Intron 2 - Exon 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PDGFA	NM_002607.5			NP_002598.4
	NM_033023.4			NP_148983.1
	XM_011515415.1			XP_011513717.1
	XM_011515416.1			XP_011513718.1
	XM_011515417.1			XP_011513719.1
	XM_011515418.1			XP_011513720.1
	A09204.1			CAA00830.1
	AB451309.1
	AB451439.1
	AK292217.1
	AU118732.1
	X03795.1			CAA27421.1
	X06374.1			CAA29677.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv950782	Chr.7:408935 - 587963 on Build GRCh38	Deletion	PRKAR1B PDGFA LOC101927000 HRAT92 LOC100131372
nsv1137568	Chr.7:516463 - 519863 on Build GRCh38	Deletion	PDGFA

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

growth factor

Gene Ontology Categories:

Process(es)

MAPK cascade
angiogenesis
response to hypoxia
cell activation
hair follicle development
positive regulation of mesenchymal cell proliferation
platelet degranulation
transforming growth factor beta receptor signaling pathway
cell-cell signaling
positive regulation of cell proliferation
response to wounding
organ morphogenesis
response to inorganic substance
negative regulation of phosphatidylinositol biosynthetic process
negative regulation of platelet activation
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of phosphatidylinositol 3-kinase signaling
regulation of smooth muscle cell migration
cell projection assembly
actin cytoskeleton organization
extracellular matrix organization
positive regulation of cell migration
positive regulation of protein autophosphorylation
response to estradiol
response to retinoic acid
regulation of actin cytoskeleton organization
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
wound healing
response to drug
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
positive regulation of GTPase activity
skin development
positive regulation of DNA replication
phosphatidylinositol phosphorylation
platelet-derived growth factor receptor signaling pathway
phosphatidylinositol-mediated signaling
positive regulation of fibroblast proliferation
lung alveolus development
inner ear development
regulation of peptidyl-tyrosine phosphorylation
negative chemotaxis
positive regulation of cell division
positive regulation of protein kinase B signaling
regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling
positive regulation of ERK1 and ERK2 cascade
regulation of glomerular mesangial cell proliferation
embryonic lung development
regulation of DNA biosynthetic process

Function(s)

Ras guanyl-nucleotide exchange factor activity
platelet-derived growth factor receptor binding
protein binding
collagen binding
growth factor activity
protein homodimerization activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
protein heterodimerization activity
platelet-derived growth factor binding