Hs01656174_cn

• Gene Symbol: PARP10
• Assay Reference Genome Location: Chr.8:143977929 on build GRCh38
• Cytoband: 8q24.3

Target Gene Details

• Entrez Gene ID: 84875
• Gene Name: poly(ADP-ribose) polymerase family member 10
• Gene Aliases: ARTD10
• Location: Chr.8:143977152-143986471 on Build GRCh38
• Assay Gene Location: Overlaps Intron 9 - Exon 9

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PARP10	NM_001317895.1			NP_001304824.1
	NM_032789.4			NP_116178.2
	NR_134234.1
	XM_011517336.2			XP_011515638.1
	AK027370.1			BAB55067.1
	AK075250.1			BAC11498.1
	AK124017.1
	AK128537.1
	AK129821.1
	AK222914.1			BAD96634.1
	AK303317.1
	BC014229.2			AAH14229.2
	BC019030.2			AAH19030.2
	BC132961.1
	BC136542.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv6445	Chr.8:143961415 - 143994522 on Build GRCh38	Insertion	PLEC PARP10 GRINA
nsv470249	Chr.8:143889098 - 144519234 on Build GRCh38	Loss	FOXH1 MIR6846 GPAA1 ADCK5 SMPD5 MROH1 RECQL4 PARP10 HSF1 KIFC2 MIR6849 TMEM249 SLC39A4 TONSL FBXL6 LOC101928953 BOP1 SCX MIR6847 SPATC1 LOC101928902 MIR7112 TONSL-AS1 MIR939 SHARPIN OPLAH DGAT1 SCRT1 CYC1 VPS28 PPP1R16A MIR661 MFSD3 CPSF1 MIR6848 MAF1 GPT PLEC HGH1 MIR6893 CYHR1 EXOSC4 LRRC14 GRINA MIR1234 SLC52A2 WDR97
nsv515809	Chr.8:143904439 - 144519234 on Build GRCh38	Gain+Loss	FOXH1 MIR6846 GPAA1 ADCK5 SMPD5 MROH1 RECQL4 PARP10 HSF1 KIFC2 MIR6849 TMEM249 SLC39A4 TONSL FBXL6 LOC101928953 BOP1 SCX MIR6847 SPATC1 LOC101928902 MIR7112 TONSL-AS1 MIR939 SHARPIN OPLAH DGAT1 SCRT1 CYC1 VPS28 PPP1R16A MIR661 MFSD3 CPSF1 MIR6848 MAF1 GPT PLEC HGH1 MIR6893 CYHR1 EXOSC4 LRRC14 GRINA MIR1234 SLC52A2 WDR97
nsv612914	Chr.8:143972494 - 144120626 on Build GRCh38	Loss	SHARPIN OPLAH MIR6846 GPAA1 SMPD5 CYC1 PARP10 MAF1 PLEC MIR6847 SPATC1 EXOSC4 GRINA WDR97
dgv12431n54	Chr.8:143845100 - 144161320 on Build GRCh38	Loss	SHARPIN OPLAH MIR6846 GPAA1 SMPD5 MROH1 CYC1 MIR661 PARP10 MAF1 PLEC HGH1 MIR6847 SPATC1 EXOSC4 GRINA EPPK1 WDR97
nsv950015	Chr.8:143866633 - 144125597 on Build GRCh38	Deletion	SHARPIN OPLAH MIR6846 GPAA1 SMPD5 CYC1 MIR661 PARP10 MAF1 PLEC MIR6847 SPATC1 EXOSC4 GRINA EPPK1 WDR97
nsv1161815	Chr.8:143775169 - 144080674 on Build GRCh38	Deletion	OPLAH MIR6846 MIR937 SMPD5 SCRIB MIR661 PARP10 MIR6845 PLEC LOC642574 PUF60 MIR6847 SPATC1 EXOSC4 GRINA EPPK1 NRBP2
nsv470250	Chr.8:143917934 - 144097007 on Build GRCh38	Gain	OPLAH MIR6846 PLEC GPAA1 SMPD5 CYC1 MIR6847 MIR661 PARP10 SPATC1 EXOSC4 GRINA
dgv12433n54	Chr.8:143902404 - 144120626 on Build GRCh38	Gain	SHARPIN OPLAH MIR6846 GPAA1 SMPD5 CYC1 MIR661 PARP10 MAF1 PLEC MIR6847 SPATC1 EXOSC4 GRINA WDR97
nsv612906	Chr.8:143917935 - 144090784 on Build GRCh38	Loss	OPLAH MIR6846 PLEC GPAA1 SMPD5 MIR6847 MIR661 PARP10 SPATC1 EXOSC4 GRINA

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

protein ADP-ribosylation
negative regulation of gene expression
regulation of chromatin assembly
negative regulation of NF-kappaB transcription factor activity
negative regulation of protein import into nucleus, translocation
negative regulation of viral genome replication
negative regulation of fibroblast proliferation
protein poly-ADP-ribosylation
protein auto-ADP-ribosylation
negative regulation of protein K63-linked ubiquitination

Function(s)

NAD+ ADP-ribosyltransferase activity
protein binding
K63-linked polyubiquitin binding