Hs01705238_cn

• Gene Symbol: PARP10
• Assay Reference Genome Location: Chr.8:143983190 on build GRCh38
• Cytoband: 8q24.3

Target Gene Details

• Entrez Gene ID: 84875
• Gene Name: poly(ADP-ribose) polymerase family member 10
• Gene Aliases: ARTD10
• Location: Chr.8:143977152-143986471 on Build GRCh38
• Assay Gene Location: Overlaps Intron 7 - Exon 7

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PARP10	NM_001317895.1			NP_001304824.1
	NM_032789.4			NP_116178.2
	NR_134234.1
	XM_011517336.2			XP_011515638.1
	AK027370.1			BAB55067.1
	AK075250.1			BAC11498.1
	AK124017.1
	AK128537.1
	AK129821.1
	AK222914.1			BAD96634.1
	AK303317.1
	BC014229.2			AAH14229.2
	BC019030.2			AAH19030.2
	BC132961.1
	BC136542.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv6445	Chr.8:143961415 - 143994522 on Build GRCh38	Insertion	PARP10 PLEC GRINA
nsv470249	Chr.8:143889098 - 144519234 on Build GRCh38	Loss	MFSD3 LRRC14 LOC101928902 OPLAH TONSL TONSL-AS1 MIR939 GRINA MIR661 SLC39A4 PPP1R16A SCX SHARPIN KIFC2 FOXH1 PARP10 MROH1 ADCK5 VPS28 PLEC GPT MIR1234 MAF1 SCRT1 HGH1 SMPD5 MIR7112 MIR6846 EXOSC4 WDR97 MIR6893 GPAA1 MIR6847 SPATC1 BOP1 LOC101928953 SLC52A2 TMEM249 CYC1 MIR6848 CYHR1 HSF1 CPSF1 RECQL4 DGAT1 MIR6849 FBXL6
nsv515809	Chr.8:143904439 - 144519234 on Build GRCh38	Gain+Loss	MFSD3 LRRC14 LOC101928902 OPLAH TONSL TONSL-AS1 MIR939 GRINA MIR661 SLC39A4 PPP1R16A SCX SHARPIN KIFC2 FOXH1 PARP10 MROH1 ADCK5 VPS28 PLEC GPT MIR1234 MAF1 SCRT1 HGH1 SMPD5 MIR7112 MIR6846 EXOSC4 WDR97 MIR6893 GPAA1 MIR6847 SPATC1 BOP1 LOC101928953 SLC52A2 TMEM249 CYC1 MIR6848 CYHR1 HSF1 CPSF1 RECQL4 DGAT1 MIR6849 FBXL6
nsv612914	Chr.8:143972494 - 144120626 on Build GRCh38	Loss	MIR6846 EXOSC4 WDR97 GPAA1 MIR6847 OPLAH GRINA SPATC1 SHARPIN PARP10 CYC1 PLEC MAF1 SMPD5
dgv12431n54	Chr.8:143845100 - 144161320 on Build GRCh38	Loss	MIR6846 EPPK1 EXOSC4 WDR97 GPAA1 MIR6847 OPLAH GRINA MIR661 SPATC1 SHARPIN PARP10 CYC1 MROH1 PLEC MAF1 HGH1 SMPD5
nsv950015	Chr.8:143866633 - 144125597 on Build GRCh38	Deletion	MIR6846 EPPK1 EXOSC4 WDR97 GPAA1 MIR6847 OPLAH GRINA MIR661 SPATC1 SHARPIN PARP10 CYC1 PLEC MAF1 SMPD5
nsv1161815	Chr.8:143775169 - 144080674 on Build GRCh38	Deletion	MIR6846 EPPK1 LOC642574 EXOSC4 MIR6847 OPLAH GRINA MIR661 SPATC1 NRBP2 MIR6845 PARP10 PUF60 MIR937 PLEC SCRIB SMPD5
nsv470250	Chr.8:143917934 - 144097007 on Build GRCh38	Gain	MIR6846 EXOSC4 PARP10 GPAA1 CYC1 MIR6847 OPLAH PLEC GRINA MIR661 SPATC1 SMPD5
dgv12433n54	Chr.8:143902404 - 144120626 on Build GRCh38	Gain	MIR6846 EXOSC4 WDR97 GPAA1 MIR6847 OPLAH GRINA MIR661 SPATC1 SHARPIN PARP10 CYC1 PLEC MAF1 SMPD5
nsv612906	Chr.8:143917935 - 144090784 on Build GRCh38	Loss	MIR6846 EXOSC4 PARP10 GPAA1 MIR6847 OPLAH PLEC GRINA MIR661 SPATC1 SMPD5

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

protein ADP-ribosylation
negative regulation of gene expression
regulation of chromatin assembly
negative regulation of NF-kappaB transcription factor activity
negative regulation of protein import into nucleus, translocation
negative regulation of viral genome replication
negative regulation of fibroblast proliferation
protein poly-ADP-ribosylation
protein auto-ADP-ribosylation
negative regulation of protein K63-linked ubiquitination

Function(s)

NAD+ ADP-ribosyltransferase activity
protein binding
K63-linked polyubiquitin binding