Hs01894286_cn

• Gene Symbol: TERF2
• Assay Reference Genome Location: Chr.16:69356030 on build GRCh38
• Cytoband: 16q22.1

Target Gene Details

• Entrez Gene ID: 7014
• Gene Name: telomeric repeat binding factor 2
• Gene Aliases: TRBF2, TRF2
• Location: Chr.16:69355561-69386004 on Build GRCh38
• Assay Gene Location: Within Exon 11

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TERF2	NM_005652.4	10	2514	NP_005643.2
	XM_005256121.3	11	2539	XP_005256178.1
	XM_005256122.3	11	2536	XP_005256179.1
	XM_005256123.3	10	2527	XP_005256180.1
	XM_005256124.3	8	2296	XP_005256181.1
	AF002999.1	10	2495	AAB81135.1
	BX090758.1	1	136

More Information

Additional Information:

For this assay, SNP(s) [rs114396464] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Exonic, non-DGV Variation

Gene Ontology Categories:

Process(es)

telomere maintenance
telomere maintenance via telomerase
cell cycle
positive regulation of gene expression
negative regulation of gene expression
telomere capping
telomeric loop formation
protection from non-homologous end joining at telomere
regulation of telomere maintenance
negative regulation of telomere maintenance
positive regulation of telomere maintenance
negative regulation of telomere maintenance via recombination
regulation of telomere maintenance via telomerase
negative regulation of telomere maintenance via semi-conservative replication
positive regulation of nitric-oxide synthase activity
protein localization to chromosome, telomeric region
cellular senescence
negative regulation of beta-galactosidase activity
negative regulation of telomere single strand break repair
negative regulation of telomere capping
negative regulation of t-circle formation
negative regulation of cellular senescence

Function(s)

double-stranded telomeric DNA binding
telomerase activity
protein binding
protein C-terminus binding
telomeric DNA binding
protein homodimerization activity
macromolecular complex binding
G-rich strand telomeric DNA binding