Hs02001770_cn

• Gene Symbol: HNRNPK
• Assay Reference Genome Location: Chr.9:83974601 on build GRCh38
• Cytoband: 9q21.32

Target Gene Details

• Entrez Gene ID: 3190
• Gene Name: heterogeneous nuclear ribonucleoprotein K
• Gene Aliases: AUKS, CSBP, HNRPK, TUNP
• Location: Chr.9:83968083-83980782 on Build GRCh38
• Assay Gene Location: Overlaps Intron 7 - Exon 8

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
HNRNPK	NM_001318186.1			NP_001305115.1
	NM_001318187.1			NP_001305116.1
	NM_001318188.1			NP_001305117.1
	NM_002140.4			NP_002131.2
	NM_031262.3			NP_112552.1
	NM_031263.3			NP_112553.1
	XM_005251960.2			XP_005252017.1
	XM_005251963.3			XP_005252020.1
	XM_005251965.2			XP_005252022.1
	XM_011518616.1			XP_011516918.1
	XM_017014668.1			XP_016870157.1
	XM_017014669.1			XP_016870158.1
	AB209562.1			BAD92799.1
	AB451263.1
	AB451390.1
	AK096385.1
	AK123117.1	1	1198
	AK291336.1
	AK294067.1
	AK300744.1
	AK307962.1
	AY911506.1			AAW84289.1
	BC000355.2			AAH00355.1
	BC014980.1			AAH14980.1
	CR456771.1			CAG33052.1
	DA394419.1
	DC318847.1
	DC407458.1
	S74678.1			AAB20770.1
	X72727.1			CAA51267.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv831644	Chr.9:83919395 - 84089480 on Build GRCh38	Gain	MIR7-1 KIF27 C9orf64 LOC105376335 HNRNPK RMI1 LOC101927575
esv2759701	Chr.9:83799109 - 83988687 on Build GRCh38	Gain	MIR7-1 GKAP1 KIF27 C9orf64 LOC105376335 HNRNPK RMI1
nsv1043703	Chr.9:83931002 - 83988630 on Build GRCh38	Gain	MIR7-1 C9orf64 HNRNPK RMI1
esv3620911	Chr.9:83964468 - 83975773 on Build GRCh38	Gain	MIR7-1 HNRNPK
nsv8541	Chr.9:83854808 - 83978843 on Build GRCh38	Gain	MIR7-1 KIF27 C9orf64 LOC105376335 HNRNPK

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

RNA metabolism protein

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
mRNA splicing, via spliceosome
ovarian follicle development
kidney development
liver development
transcription from RNA polymerase II promoter
RNA processing
acute-phase response
signal transduction
peripheral nervous system development
aging
gene expression
regulation of low-density lipoprotein particle clearance
response to activity
viral process
protein sumoylation
cerebellum development
hippocampus development
cerebral cortex development
lung development
negative regulation of protein binding
cellular response to insulin stimulus
positive regulation of RNA splicing
camera-type eye development
negative regulation of apoptotic process
positive regulation of low-density lipoprotein particle receptor biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
negative regulation of mRNA splicing, via spliceosome
positive regulation of receptor-mediated endocytosis
thymus development
positive regulation of synaptic transmission
positive regulation of dendritic spine development
cellular response to amino acid stimulus
cellular response to glucose stimulus
regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
cellular response to rapamycin
positive regulation of synapse maturation
cell-cell adhesion
positive regulation of long-term synaptic potentiation
response to salt
regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
positive regulation of dendrite extension
cellular response to forskolin
positive regulation of protein localization to cell surface
negative regulation of branching morphogenesis of a nerve

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
single-stranded DNA binding
RNA binding
mRNA 3'-UTR binding
protein binding
lamin binding
transcription factor binding
protein domain specific binding
pre-mRNA 3'-splice site binding
heat shock protein binding
actinin binding
ribonucleoprotein complex binding
poly(A) RNA binding
ATPase binding
cadherin binding involved in cell-cell adhesion
mRNA CDS binding
C-rich single-stranded DNA binding