Hs02069419_cn

• Gene Symbol: ARRB1
• Assay Reference Genome Location: Chr.11:75265784 on build GRCh38
• Cytoband: 11q13.4

Target Gene Details

• Entrez Gene ID: 408
• Gene Name: arrestin beta 1
• Gene Aliases: ARB1, ARR1
• Location: Chr.11:75260122-75351831 on Build GRCh38
• Assay Gene Location: Within Exon 20

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ARRB1	NM_004041.4	16	1860	NP_004032.2
	NM_020251.3	15	1836	NP_064647.1
	XM_011545034.2	17	1744	XP_011543336.1
	XM_011545035.2	16	1720	XP_011543337.1
	XM_017017750.1	18	1816	XP_016873239.1
	XM_017017751.1	17	1792	XP_016873240.1
	XM_017017752.1	17	1772	XP_016873241.1
	XM_017017753.1	17	1836	XP_016873242.1
	XM_017017754.1	16	1748	XP_016873243.1
	BC003636.2	16	1713	AAH03636.1
	BX402200.2	1	49
	CB853136.1	1	339
	CD365891.1	1	300

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv832211	Chr.11:75234794 - 75395081 on Build GRCh38	Loss	ARRB1 TPBGL MIR326
dgv1225n100	Chr.11:75226932 - 75348452 on Build GRCh38	Gain	ARRB1 TPBGL MIR326
esv3626851	Chr.11:75224463 - 75334026 on Build GRCh38	Gain	ARRB1 TPBGL

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

activation of MAPK activity
positive regulation of protein phosphorylation
G-protein coupled receptor internalization
positive regulation of receptor internalization
transcription from RNA polymerase II promoter
apoptotic process
phototransduction
protein transport
protein ubiquitination
platelet activation
negative regulation of protein ubiquitination
positive regulation of protein ubiquitination
negative regulation of NF-kappaB transcription factor activity
positive regulation of protein binding
negative regulation of interleukin-6 production
negative regulation of interleukin-8 production
positive regulation of peptidyl-serine phosphorylation
negative regulation of GTPase activity
positive regulation of smooth muscle cell apoptotic process
positive regulation of Rho protein signal transduction
positive regulation of histone acetylation
positive regulation of insulin secretion involved in cellular response to glucose stimulus
response to antidepressant
follicle-stimulating hormone signaling pathway
stress fiber assembly
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of GTPase activity
positive regulation of transcription from RNA polymerase II promoter
negative regulation of ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
positive regulation of histone H4 acetylation

Function(s)

histone acetyltransferase activity
enzyme inhibitor activity
GTPase activator activity
insulin-like growth factor receptor binding
protein binding
transcription factor binding
estrogen receptor binding
mitogen-activated protein kinase kinase binding
ubiquitin protein ligase binding
alpha-1A adrenergic receptor binding
alpha-1B adrenergic receptor binding
angiotensin receptor binding
follicle-stimulating hormone receptor binding
V2 vasopressin receptor binding
AP-2 adaptor complex binding
clathrin adaptor activity
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
transcription regulatory region DNA binding
ion channel binding
protein phosphorylated amino acid binding