Hs02233004_cn

• Gene Symbol: PARP10
• Assay Reference Genome Location: Chr.8:143984011 on build GRCh38
• Cytoband: 8q24.3

Target Gene Details

• Entrez Gene ID: 84875
• Gene Name: poly(ADP-ribose) polymerase family member 10
• Gene Aliases: ARTD10
• Location: Chr.8:143977152-143986471 on Build GRCh38
• Assay Gene Location: Overlaps Intron 6 - Exon 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PARP10	NM_001317895.1			NP_001304824.1
	NM_032789.4			NP_116178.2
	NR_134234.1
	XM_011517336.2			XP_011515638.1
	AK027370.1			BAB55067.1
	AK075250.1			BAC11498.1
	AK124017.1	1	348
	AK128537.1
	AK129821.1
	AK222914.1			BAD96634.1
	AK303317.1
	BC019030.2			AAH19030.2
	BC132961.1
	BC136542.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv6445	Chr.8:143961415 - 143994522 on Build GRCh38	Insertion	GRINA PLEC PARP10
nsv470249	Chr.8:143889098 - 144519234 on Build GRCh38	Loss	EXOSC4 MAF1 FBXL6 KIFC2 CYHR1 DGAT1 MIR6847 BOP1 GPT LOC101928953 HGH1 FOXH1 MIR6846 SCX MFSD3 GRINA PLEC MIR6849 LOC101928902 TONSL SLC52A2 MIR6893 VPS28 ADCK5 MIR1234 PPP1R16A MIR661 OPLAH HSF1 SMPD5 MIR6848 SPATC1 PARP10 TMEM249 GPAA1 SCRT1 SHARPIN WDR97 CYC1 TONSL-AS1 RECQL4 MIR7112 MROH1 SLC39A4 LRRC14 MIR939 CPSF1
nsv515809	Chr.8:143904439 - 144519234 on Build GRCh38	Gain+Loss	EXOSC4 MAF1 FBXL6 KIFC2 CYHR1 DGAT1 MIR6847 BOP1 GPT LOC101928953 HGH1 FOXH1 MIR6846 SCX MFSD3 GRINA PLEC MIR6849 LOC101928902 TONSL SLC52A2 MIR6893 VPS28 ADCK5 MIR1234 PPP1R16A MIR661 OPLAH HSF1 SMPD5 MIR6848 SPATC1 PARP10 TMEM249 GPAA1 SCRT1 SHARPIN WDR97 CYC1 TONSL-AS1 RECQL4 MIR7112 MROH1 SLC39A4 LRRC14 MIR939 CPSF1
nsv612914	Chr.8:143972494 - 144120626 on Build GRCh38	Loss	EXOSC4 MAF1 MIR6847 OPLAH SMPD5 SPATC1 PARP10 GPAA1 SHARPIN WDR97 CYC1 MIR6846 GRINA PLEC
dgv12431n54	Chr.8:143845100 - 144161320 on Build GRCh38	Loss	EXOSC4 MAF1 MIR661 MIR6847 OPLAH SMPD5 SPATC1 PARP10 GPAA1 SHARPIN WDR97 CYC1 HGH1 MIR6846 GRINA PLEC MROH1 EPPK1
nsv950015	Chr.8:143866633 - 144125597 on Build GRCh38	Deletion	EXOSC4 MAF1 MIR661 MIR6847 OPLAH SMPD5 SPATC1 PARP10 GPAA1 SHARPIN WDR97 CYC1 MIR6846 GRINA PLEC EPPK1
nsv1161815	Chr.8:143775169 - 144080674 on Build GRCh38	Deletion	EXOSC4 MIR937 LOC642574 MIR6845 MIR661 MIR6847 OPLAH SMPD5 SPATC1 PARP10 SCRIB MIR6846 GRINA PLEC NRBP2 EPPK1 PUF60
nsv470250	Chr.8:143917934 - 144097007 on Build GRCh38	Gain	EXOSC4 MIR6846 GRINA PLEC MIR661 MIR6847 OPLAH SMPD5 SPATC1 PARP10 GPAA1 CYC1
dgv12433n54	Chr.8:143902404 - 144120626 on Build GRCh38	Gain	EXOSC4 MAF1 MIR661 MIR6847 OPLAH SMPD5 SPATC1 PARP10 GPAA1 SHARPIN WDR97 CYC1 MIR6846 GRINA PLEC
nsv612906	Chr.8:143917935 - 144090784 on Build GRCh38	Loss	EXOSC4 MIR6846 GRINA PLEC MIR661 MIR6847 OPLAH SMPD5 SPATC1 PARP10 GPAA1

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

protein ADP-ribosylation
negative regulation of gene expression
regulation of chromatin assembly
negative regulation of NF-kappaB transcription factor activity
negative regulation of protein import into nucleus, translocation
negative regulation of viral genome replication
negative regulation of fibroblast proliferation
protein poly-ADP-ribosylation
protein auto-ADP-ribosylation
negative regulation of protein K63-linked ubiquitination

Function(s)

NAD+ ADP-ribosyltransferase activity
protein binding
K63-linked polyubiquitin binding