Hs02244919_cn

• Gene Symbol: LILRB4
• Assay Reference Genome Location: Chr.19:54664237 on build GRCh38
• Cytoband: 19q13.42

Target Gene Details

• Entrez Gene ID: 11006
• Gene Name: leukocyte immunoglobulin like receptor B4
• Gene Aliases: CD85K, ILT-3, ILT3, LIR-5, LIR5
• Location: Chr.19:54662524-54670359 on Build GRCh38
• Assay Gene Location: Within Exon 5

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
LILRB4	NM_001278426.3	4	622	NP_001265355.2
	NM_001278427.3	4	622	NP_001265356.2
	NM_001278428.3	4	622	NP_001265357.2
	NM_001278429.3	3	586	NP_001265358.2
	NM_001278430.3	4	622	NP_001265359.2
	XM_017026215.1	5	646	XP_016881704.1
	XM_017026216.1	4	622	XP_016881705.1
	XM_017026217.1	4	622	XP_016881706.1
	AF025532.1	4	436	AAB87666.1
	AF283988.1	4	446	AAL36992.1
	AK292082.1	4	486
	AK309227.1	3	385
	AK314783.1	3	435
	BC026309.1	4	441	AAH26309.1
	BU175229.1	6	723
	CR542048.1	4	407	CAG46845.1
	EU915607.1	4	445
	U82979.1	4	407	AAC51355.1
	U91925.1	4	452	AAB68665.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv518953	Chr.19:54662091 - 54671963 on Build GRCh38	Loss	LILRB4
nsv580241	Chr.19:54632002 - 54671963 on Build GRCh38	Loss	MIR8061 LILRB4 LILRB1
esv2718879	Chr.19:54636010 - 54667235 on Build GRCh38	Deletion	MIR8061 LILRB4 LILRB1
nsv1160664	Chr.19:54631479 - 54670475 on Build GRCh38	Deletion	MIR8061 LILRB4 LILRB1
nsv428372	Chr.19:54596370 - 54954956 on Build GRCh38	Gain+Loss	LILRA1 LOC101928804 LILRP2 MIR8061 KIR2DL3 KIR2DL1 KIR2DS4 FCAR LOC102724300 KIR3DL1 NCR1 KIR2DL4 KIR3DL3 NLRP7 LILRB4 KIR3DL2 LILRB1
nsv9760	Chr.19:54636490 - 54667631 on Build GRCh38	Loss	MIR8061 LILRB4 LILRB1
nsv458799	Chr.19:54618453 - 54666478 on Build GRCh38	Gain	MIR8061 LILRB4 LILRB1
esv2758771	Chr.19:54163847 - 54954956 on Build GRCh38	Gain+Loss	LILRP2 MIR8061 LILRA2 KIR2DS4 FCAR LILRA5 LILRB2 LILRB3 TSEN34 CDC42EP5 NCR1 LENG8-AS1 LILRA4 LENG8 KIR2DL4 NLRP7 LILRB4 KIR3DL2 LILRB1 LILRA1 LOC101928804 RPS9 KIR3DX1 KIR2DL3 KIR2DL1 TMC4 MBOAT7 TTYH1 LOC102724300 LAIR1 LILRA6 KIR3DL1 MIR4752 LAIR2 LENG9 KIR3DL3 LILRB5
esv2718872	Chr.19:54472594 - 55094247 on Build GRCh38	Deletion	LILRP2 MIR8061 LILRA2 KIR2DS4 FCAR CDC42EP5 NCR1 KIR2DL4 NLRP7 LILRB4 KIR3DL2 LILRB1 LILRA1 LOC101928804 RDH13 KIR3DX1 KIR2DL3 KIR2DL1 LOC102724300 EPS8L1 KIR3DL1 LAIR2 NLRP2 PPP1R12C GP6 KIR3DL3
nsv523723	Chr.19:54637036 - 54666689 on Build GRCh38	Loss	MIR8061 LILRB4 LILRB1
esv2422341	Chr.19:54654698 - 54677097 on Build GRCh38	Duplication	LILRB4
dgv3665n100	Chr.19:54639933 - 54664828 on Build GRCh38	Gain	MIR8061 LILRB4
nsv828639	Chr.19:54636968 - 54666550 on Build GRCh38	Loss	MIR8061 LILRB4 LILRB1
nsv470158	Chr.19:54519000 - 54666689 on Build GRCh38	Loss	LILRA1 MIR8061 LILRA2 KIR3DX1 LILRB4 LILRB1
esv2667609	Chr.19:54472514 - 55094226 on Build GRCh38	Deletion	LILRP2 MIR8061 LILRA2 KIR2DS4 FCAR CDC42EP5 NCR1 KIR2DL4 NLRP7 LILRB4 KIR3DL2 LILRB1 LILRA1 LOC101928804 RDH13 KIR3DX1 KIR2DL3 KIR2DL1 LOC102724300 EPS8L1 KIR3DL1 LAIR2 NLRP2 PPP1R12C GP6 KIR3DL3
nsv1061041	Chr.19:54640223 - 54664828 on Build GRCh38	Loss	MIR8061 LILRB4
dgv16e196	Chr.19:54575263 - 54747293 on Build GRCh38	Duplication	LILRA1 LILRP2 MIR8061 LILRA2 KIR2DL3 KIR3DL3 LILRB4 LILRB1
nsv524470	Chr.19:54662761 - 54671963 on Build GRCh38	Gain	LILRB4
dgv17e196	Chr.19:54575991 - 54733430 on Build GRCh38	Deletion	LILRA1 LILRP2 MIR8061 LILRA2 KIR3DL3 LILRB4 LILRB1
nsv833879	Chr.19:54662616 - 54866141 on Build GRCh38	Gain+Loss	LOC101928804 KIR3DL1 LILRP2 KIR2DL3 KIR2DL1 KIR2DS4 LOC102724300 KIR2DL4 KIR3DL3 LILRB4 KIR3DL2
nsv580243	Chr.19:54651887 - 54665084 on Build GRCh38	Gain	LILRB4
esv2763132	Chr.19:54639945 - 54664840 on Build GRCh38	Gain+Loss	MIR8061 LILRB4

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

immunoglobulin receptor superfamily

Gene Ontology Categories:

Process(es)

adaptive immune response
signal transduction
negative regulation of osteoclast differentiation
negative regulation of pri-miRNA transcription from RNA polymerase II promoter

Function(s)

antigen binding
receptor activity
protein binding