Hs02334249_cn

• Gene Symbol: SOCS3
• Assay Reference Genome Location: Chr.17:78357769 on build GRCh38
• Cytoband: 17q25.3

Target Gene Details

• Entrez Gene ID: 9021
• Gene Name: suppressor of cytokine signaling 3
• Gene Aliases: ATOD4, CIS3, Cish3, SOCS-3, SSI-3, SSI3
• Location: Chr.17:78356777-78360079 on Build GRCh38
• Assay Gene Location: Within Exon 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SOCS3	NM_003955.4	2	1745	NP_003946.3
	BC060858.1	2	1743	AAH60858.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv833555	Chr.17:78356467 - 78461269 on Build GRCh38	Loss	SOCS3 LOC101928674 DNAH17 PGS1

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

kinase modulator

Gene Ontology Categories:

Process(es)

response to hypoxia
negative regulation of protein kinase activity
JAK-STAT cascade
aging
response to heat
response to gamma radiation
protein ubiquitination
cytokine-mediated signaling pathway
organ regeneration
response to food
response to estradiol
response to lipopolysaccharide
response to progesterone
response to insulin
regulation of growth
response to drug
negative regulation of tyrosine phosphorylation of Stat1 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
negative regulation of tyrosine phosphorylation of Stat3 protein
negative regulation of apoptotic process
positive regulation of cell differentiation
negative regulation of JAK-STAT cascade
negative regulation of insulin receptor signaling pathway
negative regulation of inflammatory response
response to glucocorticoid
regulation of interferon-gamma-mediated signaling pathway
branching involved in labyrinthine layer morphogenesis
placenta blood vessel development
trophoblast giant cell differentiation
spongiotrophoblast differentiation

Function(s)

protein kinase inhibitor activity
protein binding