Hs02373326_cn

• Gene Symbol: MAP3K12
• Assay Reference Genome Location: Chr.12:53483679 on build GRCh38
• Cytoband: 12q13.13

Target Gene Details

• Entrez Gene ID: 7786
• Gene Name: mitogen-activated protein kinase kinase kinase 12
• Gene Aliases: DLK, MEKK12, MUK, ZPK, ZPKP1
• Location: Chr.12:53480492-53501066 on Build GRCh38
• Assay Gene Location: Within Exon 13

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
MAP3K12	NM_001193511.1	9	1674	NP_001180440.1
	NM_006301.3	10	1575	NP_006292.3
	XM_005269138.3	9	1602	XP_005269195.1
	XM_006719588.3	9	1496	XP_006719651.1
	XM_011538725.2	9	2479	XP_011537027.1
	XM_017019956.1	10	1503	XP_016875445.1
	AB209453.1	4	2525	BAD92690.1
	AK094195.1	9	1470
	AK314530.1	9	1833
	BC050050.1	9	1675	AAH50050.1
	U07358.1	10	1402	AAA67343.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv714	Chr.12:53455169 - 53489159 on Build GRCh38	Insertion	PCBP2-OT1 MAP3K12 PCBP2

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

activation of MAPKK activity
protein phosphorylation
JNK cascade
histone phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
intracellular signal transduction
protein autophosphorylation
mitophagy in response to mitochondrial depolarization
negative regulation of motor neuron apoptotic process

Function(s)

protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase kinase activity
protein binding
ATP binding
protein kinase binding
protein homodimerization activity