Hs02498597_cn

• Gene Symbol: PARP1
• Assay Reference Genome Location: Chr.1:226361943 on build GRCh38
• Cytoband: 1q42.12

Target Gene Details

• Entrez Gene ID: 142
• Gene Name: poly(ADP-ribose) polymerase 1
• Gene Aliases: ADPRT, ADPRT 1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1
• Location: Chr.1:226360691-226408100 on Build GRCh38
• Assay Gene Location: Overlaps Intron 22 - Exon 22

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PARP1	NM_001618.3			NP_001609.2
	AK125650.1
	AK225654.1
	AK303340.1
	AK312339.1
	BC037545.1			AAH37545.1
	J03473.1			AAB59447.1
	M17081.1			AAA51599.1
	M18112.1			AAA60137.1
	M32721.1			AAA60155.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv832770	Chr.1:226277429 - 226467811 on Build GRCh38	Loss	LIN9 PARP1

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

DNA metabolism protein

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
nucleotide-excision repair, DNA damage recognition
nucleotide-excision repair, DNA duplex unwinding
double-strand break repair via homologous recombination
lagging strand elongation
DNA repair
nucleotide-excision repair, preincision complex stabilization
nucleotide-excision repair, preincision complex assembly
nucleotide-excision repair, DNA incision, 3'-to lesion
nucleotide-excision repair, DNA incision, 5'-to lesion
double-strand break repair
transcription from RNA polymerase II promoter
protein ADP-ribosylation
cellular response to DNA damage stimulus
mitochondrion organization
transforming growth factor beta receptor signaling pathway
positive regulation of cardiac muscle hypertrophy
protein autoprocessing
protein sumoylation
signal transduction involved in regulation of gene expression
macrophage differentiation
mitochondrial DNA metabolic process
cellular response to insulin stimulus
nucleotide-excision repair, DNA incision
cellular response to oxidative stress
protein modification process
DNA damage response, detection of DNA damage
mitochondrial DNA repair
positive regulation of transcription from RNA polymerase II promoter
DNA ligation involved in DNA repair
positive regulation of SMAD protein import into nucleus
protein poly-ADP-ribosylation
global genome nucleotide-excision repair
regulation of cellular protein localization
negative regulation of telomere maintenance via telomere lengthening
ATP generation from poly-ADP-D-ribose
positive regulation of transcription regulatory region DNA binding

Function(s)

DNA binding
DNA ligase (ATP) activity
NAD+ ADP-ribosyltransferase activity
protein binding
transcription factor binding
zinc ion binding
enzyme binding
protein kinase binding
identical protein binding
histone deacetylase binding
poly(A) RNA binding
protein N-terminus binding
NAD binding
R-SMAD binding