Hs02526640_cn

• Gene Symbol: GCLC
• Assay Reference Genome Location: Chr.6:53498418 on build GRCh38
• Cytoband: 6p12.1

Target Gene Details

• Entrez Gene ID: 2729
• Gene Name: glutamate-cysteine ligase catalytic subunit
• Gene Aliases: GCL, GCS, GLCL, GLCLC
• Location: Chr.6:53497341-53545129 on Build GRCh38
• Assay Gene Location: Within Exon 16

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
GCLC	NM_001197115.1	15	2622	NP_001184044.1
	NM_001498.3	16	2736	NP_001489.1
	XM_017010749.1	16	2361	XP_016866238.1
	AB262176.1	16	2639
	AK094940.1	1	1093
	AK304288.1
	BC039894.1	16	2334	AAH39894.1
	M90656.1	16	2344	AAA58499.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2763940	Chr.6:53228517 - 53622284 on Build GRCh38	Gain+Loss	GCLC MIR5685 RPS16P5 ELOVL5 GCM1 LOC101927136

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

ligase

Gene Ontology Categories:

Process(es)

sulfur amino acid metabolic process
cysteine metabolic process
glutamate metabolic process
glutathione biosynthetic process
response to oxidative stress
apoptotic mitochondrial changes
response to heat
response to xenobiotic stimulus
response to hormone
L-ascorbic acid metabolic process
negative regulation of protein ubiquitination
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
cell redox homeostasis
negative regulation of transcription, DNA-templated
response to arsenic-containing substance
regulation of blood vessel size
response to nitrosative stress
regulation of mitochondrial depolarization
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

magnesium ion binding
glutamate-cysteine ligase activity
ATP binding
glutamate binding
ADP binding
protein heterodimerization activity
coenzyme binding