Hs02589167_cn

• Gene Symbol: AURKB
• Assay Reference Genome Location: Chr.17:8206621 on build GRCh38
• Cytoband: 17p13.1

Target Gene Details

• Entrez Gene ID: 9212
• Gene Name: aurora kinase B
• Gene Aliases: AIK2, AIM-1, AIM1, ARK2, AurB, IPL1, PPP1R48, STK12, STK5, aurkb-sv1, aurkb-sv2
• Location: Chr.17:8204731-8210768 on Build GRCh38
• Assay Gene Location: Overlaps Intron 7 - Exon 8

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
AURKB	NM_001256834.2			NP_001243763.1
	NM_001284526.1			NP_001271455.1
	NM_001313950.1			NP_001300879.1
	NM_001313951.1			NP_001300880.1
	NM_001313952.1			NP_001300881.1
	NM_001313953.1			NP_001300882.1
	NM_001313954.1			NP_001300883.1
	NM_001313955.1			NP_001300884.1
	NM_004217.3			NP_004208.2
	NR_132730.1
	NR_132731.1
	XM_011524070.2			XP_011522372.1
	XM_011524072.2			XP_011522374.1
	XM_017025307.1			XP_016880796.1
	XM_017025308.1			XP_016880797.1
	XM_017025309.1			XP_016880798.1
	XM_017025310.1			XP_016880799.1
	XM_017025311.1			XP_016880800.1
	AB011446.1			BAA82709.1
	AB011450.1			BAA32136.1
	AB519677.1
	AB519678.1
	AB519679.1
	AF004022.1			AAB65786.1
	AF008552.1			AAC12709.1
	AF015254.1			AAC98891.1
	AK297976.1
	AK314889.1
	AY677083.1
	BC000442.2
	BC009751.2			AAH09751.1
	BC013300.2			AAH13300.2
	BC080581.1			AAH80581.1
	BE514591.1
	BE797606.1
	BI199088.1
	BM905813.1
	BT019534.1			AAV38341.1
	BU181480.1
	CN286704.1
	CX781462.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3639878	Chr.17:8193720 - 8214825 on Build GRCh38	Loss	AURKB
nsv833353	Chr.17:8150060 - 8326783 on Build GRCh38	Loss	PER1 LINC00324 SNORD118 BORCS6 PFAS TMEM107 MIR4521 SLC25A35 CTC1 AURKB VAMP2 ARHGEF15 RANGRF

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
negative regulation of B cell apoptotic process
protein phosphorylation
spindle organization
sister chromatid cohesion
aging
cell proliferation
attachment of spindle microtubules to kinetochore
abscission
histone modification
protein sumoylation
anaphase-promoting complex-dependent catabolic process
spindle checkpoint
negative regulation of protein binding
positive regulation of telomere maintenance via telomerase
negative regulation of cytokinesis
positive regulation of cytokinesis
protein localization to kinetochore
cellular response to UV
cleavage furrow formation
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
histone H3-S28 phosphorylation
protein autophosphorylation
mitotic spindle midzone assembly
positive regulation of telomerase activity
regulation of chromosome segregation
regulation of signal transduction by p53 class mediator
positive regulation of telomere capping

Function(s)

protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein binding
ATP binding
histone serine kinase activity
metal ion binding