Hs02648218_cn

• Gene Symbol: CCNA2
• Assay Reference Genome Location: Chr.4:121816459 on build GRCh38
• Cytoband: 4q27

Target Gene Details

• Entrez Gene ID: 890
• Gene Name: cyclin A2
• Gene Aliases: CCN1, CCNA
• Location: Chr.4:121816444-121823933 on Build GRCh38
• Assay Gene Location: Overlaps - Exon 8

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
CCNA2	NM_001237.3			NP_001228.1

Target Gene Details

• Entrez Gene ID: 5393
• Gene Name: exosome component 9
• Gene Aliases: PM/Scl-75, PMSCL1, RRP45, Rrp45p, p5, p6
• Location: Chr.4:121801295-121817021 on Build GRCh38
• Assay Gene Location: Overlaps Exon 13 - Intron 13

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
EXOSC9	NM_001034194.1			NP_001029366.1
	NM_005033.2			NP_005024.2
	AJ505989.1			CAD44530.1
	AJ517294.1			CAD56889.1
	AK307548.1
	BC142978.1
	BU615347.1
	BX649106.1
	M58460.1			AAA58384.1
	U09215.1			AAA18832.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv997539	Chr.4:121622949 - 122353111 on Build GRCh38	Gain	ANXA5 BBS7 EXOSC9 TRPC3 CCNA2 KIAA1109 PP12613 TMEM155
esv3602016	Chr.4:121811764 - 121818497 on Build GRCh38	Gain	EXOSC9 CCNA2

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

kinase activator, RNA metabolism protein, exoribonuclease, nucleic acid metabolism protein

Gene Ontology Categories:

Process(es)

regulation of cyclin-dependent protein serine/threonine kinase activity
mitotic nuclear division
mitotic G2 DNA damage checkpoint
Ras protein signal transduction
viral process
organ regeneration
response to glucagon
cellular response to platelet-derived growth factor stimulus
cellular response to leptin stimulus
positive regulation of transcription, DNA-templated
positive regulation of fibroblast proliferation
cell division
cellular response to cocaine
cellular response to luteinizing hormone stimulus
cellular response to estradiol stimulus
cellular response to hypoxia
cellular response to nitric oxide
cochlea development
cellular response to insulin-like growth factor stimulus
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
nuclear-transcribed mRNA catabolic process
rRNA processing
immune response
positive regulation of cell growth
nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
U1 snRNA 3'-end processing
U4 snRNA 3'-end processing
U5 snRNA 3'-end processing
regulation of mRNA stability
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
nuclear mRNA surveillance
nuclear polyadenylation-dependent rRNA catabolic process
nuclear polyadenylation-dependent tRNA catabolic process
nuclear polyadenylation-dependent mRNA catabolic process

Function(s)

protein binding
protein kinase binding
3'-5'-exoribonuclease activity
RNA binding
exoribonuclease activity
AU-rich element binding
poly(A) RNA binding