Hs02856896_cn

• Gene Symbol: E2F4
• Assay Reference Genome Location: Chr.16:67192707 on build GRCh38
• Cytoband: 16q22.1

Target Gene Details

• Entrez Gene ID: 1874
• Gene Name: E2F transcription factor 4
• Gene Aliases: E2F-4
• Location: Chr.16:67192165-67198918 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
E2F4	NM_001950.3			NP_001941.2
	AB451292.1
	AB451425.1
	BC033180.1			AAH33180.1
	S75174.1			AAB32597.1
	U15641.1			AAC50119.1
	X86096.1			CAA60050.2

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv522852	Chr.16:67153308 - 68071571 on Build GRCh38	Gain	ACD ZDHHC1 LRRC29 SLC9A5 TRADD CTRL DPEP3 DUS2 THAP11 LOC107984813 TMEM208 EDC4 AGRP DPEP2 LOC100505942 LCAT SLC12A4 PLEKHG4 LOC100131303 E2F4 HSD11B2 MIR328 TPPP3 LRRC36 CENPT NOL3 HSF4 GFOD2 DDX28 PARD6A FHOD1 PSKH1 LOC105369155 NUTF2 ATP6V0D1 FAM65A ENKD1 PSMB10 CARMIL2 NRN1L KIAA0895L CTCF EXOC3L1 FBXL8 TSNAXIP1 C16orf86 KCTD19 RANBP10 ELMO3
nsv827707	Chr.16:67148355 - 67289296 on Build GRCh38	Loss	NOL3 HSF4 LRRC29 SLC9A5 KIAA0895L TRADD EXOC3L1 FBXL8 PLEKHG4 E2F4 B3GNT9 FHOD1 LOC105369155 ELMO3 TMEM208 C16orf70 MIR328
nsv952044	Chr.16:67141198 - 67244397 on Build GRCh38	Deletion	NOL3 HSF4 LRRC29 KIAA0895L TRADD EXOC3L1 FBXL8 E2F4 B3GNT9 FHOD1 LOC105369155 ELMO3 TMEM208 C16orf70 MIR328
nsv1160429	Chr.16:67161549 - 67220197 on Build GRCh38	Deletion	LOC105369155 NOL3 HSF4 LRRC29 KIAA0895L EXOC3L1 FBXL8 ELMO3 E2F4 MIR328
nsv457513	Chr.16:67181417 - 67282697 on Build GRCh38	Loss	LOC105369155 LRRC29 SLC9A5 KIAA0895L EXOC3L1 PLEKHG4 ELMO3 TMEM208 E2F4 MIR328 FHOD1
nsv524492	Chr.16:67174030 - 67294550 on Build GRCh38	Loss	NOL3 LRRC29 SLC9A5 KIAA0895L EXOC3L1 PLEKHG4 E2F4 FHOD1 LOC105369155 KCTD19 ELMO3 TMEM208 MIR328
nsv524363	Chr.16:67136529 - 68071571 on Build GRCh38	Loss	ACD ZDHHC1 LRRC29 SLC9A5 TRADD CTRL DPEP3 DUS2 THAP11 LOC107984813 TMEM208 EDC4 AGRP DPEP2 LOC100505942 LCAT SLC12A4 PLEKHG4 LOC100131303 E2F4 HSD11B2 B3GNT9 MIR328 TPPP3 LRRC36 CENPT NOL3 HSF4 GFOD2 DDX28 PARD6A FHOD1 PSKH1 LOC105369155 NUTF2 ATP6V0D1 FAM65A ENKD1 PSMB10 C16orf70 CARMIL2 NRN1L KIAA0895L CTCF EXOC3L1 FBXL8 TSNAXIP1 C16orf86 KCTD19 RANBP10 ELMO3

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

RNA metabolism protein, nucleic acid metabolism protein, general transcription factor

Gene Ontology Categories:

Process(es)

regulation of transcription involved in G1/S transition of mitotic cell cycle
epithelial cell development
transcription from RNA polymerase II promoter
cell volume homeostasis
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
blood circulation
organ morphogenesis
regulation of cell proliferation
motile cilium assembly
positive regulation of transcription from RNA polymerase II promoter
centriole assembly
multi-ciliated epithelial cell differentiation

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
protein domain specific binding
promoter-specific chromatin binding