Hs02870886_cn

• Gene Symbol: STAT1
• Assay Reference Genome Location: Chr.2:190969292 on build GRCh38
• Cytoband: 2q32.2

Target Gene Details

• Entrez Gene ID: 6772
• Gene Name: signal transducer and activator of transcription 1
• Gene Aliases: CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91
• Location: Chr.2:190969036-191014250 on Build GRCh38
• Assay Gene Location: Within Exon 26

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
STAT1	NM_007315.3	25	4052	NP_009330.1
	XM_006712718.1	24	3845	XP_006712781.1
	XM_017004783.1	26	4082	XP_016860272.1
	AI992149.1	1	147
	BU738296.1	1	275
	CR749636.1			CAH18430.1
	EB385742.1
	M97935.1	24	3860	AAB64012.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv999391	Chr.2:190884309 - 191057205 on Build GRCh38	Gain	STAT1 STAT4 LOC105373805 GLS
nsv834493	Chr.2:190946647 - 191109514 on Build GRCh38	Gain	STAT1 STAT4 LOC105373805 GLS
nsv584065	Chr.2:190779811 - 191011175 on Build GRCh38	Loss	STAT1 GLS

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

DNA-binding transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
negative regulation of endothelial cell proliferation
positive regulation of mesenchymal cell proliferation
negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
transcription, DNA-templated
apoptotic process
JAK-STAT cascade
blood circulation
macrophage derived foam cell differentiation
negative regulation of angiogenesis
tumor necrosis factor-mediated signaling pathway
response to cytokine
response to interferon-beta
cellular response to interferon-beta
regulation of apoptotic process
negative regulation of I-kappaB kinase/NF-kappaB signaling
response to peptide hormone
endothelial cell migration
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation by virus of viral protein levels in host cell
positive regulation of smooth muscle cell proliferation
response to cAMP
defense response to virus
interferon-gamma-mediated signaling pathway
regulation of interferon-gamma-mediated signaling pathway
type I interferon signaling pathway
regulation of type I interferon-mediated signaling pathway
renal tubule development
cellular response to organic cyclic compound
metanephric mesenchymal cell proliferation involved in metanephros development
metanephric mesenchymal cell differentiation
negative regulation of metanephric nephron tubule epithelial cell differentiation
cell-cell adhesion

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter sequence-specific
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
signal transducer activity
tumor necrosis factor receptor binding
protein binding
enzyme binding
nuclear hormone receptor binding
identical protein binding
protein homodimerization activity
cadherin binding involved in cell-cell adhesion