Hs02941897_cn

• Gene Symbol: SOX11
• Assay Reference Genome Location: Chr.2:5697404 on build GRCh38
• Cytoband: 2p25.2

Target Gene Details

• Entrez Gene ID: 6664
• Gene Name: SRY-box 11
• Gene Aliases: MRD27
• Location: Chr.2:5692667-5701385 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SOX11	NM_003108.3	1	4738	NP_003099.1
	AB028641.1	1	4738	BAA88122.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv833292	Chr.2:5663369 - 5827989 on Build GRCh38	Gain+Loss	SOX11 LINC01248
dgv609n67	Chr.2:5665874 - 5710795 on Build GRCh38	Gain	SOX11 LINC01248
dgv608n67	Chr.2:5647093 - 5731885 on Build GRCh38	Gain	SOX11 LINC01248
nsv953442	Chr.2:5690269 - 5697668 on Build GRCh38	Deletion	SOX11 LINC01248

More Information

Additional Information:

For this assay, SNP(s) [rs112726300] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

HMG box transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
skeletal system development
kidney development
neural tube formation
lens morphogenesis in camera-type eye
outflow tract morphogenesis
cardiac ventricle formation
noradrenergic neuron differentiation
transcription from RNA polymerase II promoter
translation
positive regulation of cell proliferation
positive regulation of gene expression
negative regulation of gene expression
oligodendrocyte development
glial cell proliferation
neural crest cell development
regulation of transforming growth factor beta receptor signaling pathway
spinal cord development
glial cell development
neuron differentiation
positive regulation of BMP signaling pathway
positive regulation of hippo signaling
skeletal muscle cell differentiation
positive regulation of neuron differentiation
positive regulation of osteoblast differentiation
positive regulation of ossification
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of hormone secretion
sympathetic nervous system development
embryonic digestive tract morphogenesis
embryonic skeletal system morphogenesis
negative regulation of lymphocyte proliferation
positive regulation of neurogenesis
hard palate development
soft palate development
limb bud formation
negative regulation of glial cell proliferation
ventricular septum morphogenesis
lung morphogenesis
negative regulation of cell death
neuroepithelial cell differentiation
eyelid development in camera-type eye
somite development
cornea development in camera-type eye
closure of optic fissure
signal transduction involved in cell cycle checkpoint
positive regulation of stem cell proliferation
negative regulation of transcription regulatory region DNA binding
positive regulation of lens epithelial cell proliferation

Function(s)

transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription coactivator activity
enhancer sequence-specific DNA binding
transcription factor activity, sequence-specific DNA binding
translation factor activity, RNA binding