Hs02946357_cn

• Gene Symbol: E2F4
• Assay Reference Genome Location: Chr.16:67193157 on build GRCh38
• Cytoband: 16q22.1

Target Gene Details

• Entrez Gene ID: 1874
• Gene Name: E2F transcription factor 4
• Gene Aliases: E2F-4
• Location: Chr.16:67192165-67198918 on Build GRCh38
• Assay Gene Location: Overlaps Exon 3 - Intron 3

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
E2F4	NM_001950.3			NP_001941.2
	AB451292.1
	AB451425.1
	BC033180.1			AAH33180.1
	S75174.1			AAB32597.1
	U15641.1			AAC50119.1
	X86096.1			CAA60050.2

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv522852	Chr.16:67153308 - 68071571 on Build GRCh38	Gain	E2F4 FAM65A EXOC3L1 LCAT AGRP TSNAXIP1 DPEP2 CENPT THAP11 LOC105369155 KIAA0895L C16orf86 LOC107984813 CARMIL2 MIR328 KCTD19 HSF4 LRRC36 PARD6A SLC9A5 NRN1L FHOD1 LRRC29 RANBP10 DPEP3 TPPP3 EDC4 ELMO3 CTCF TMEM208 DDX28 ATP6V0D1 PSMB10 LOC100505942 ZDHHC1 PSKH1 SLC12A4 ENKD1 DUS2 CTRL NUTF2 NOL3 LOC100131303 GFOD2 HSD11B2 ACD PLEKHG4 TRADD FBXL8
nsv827707	Chr.16:67148355 - 67289296 on Build GRCh38	Loss	E2F4 B3GNT9 MIR328 TMEM208 EXOC3L1 HSF4 NOL3 SLC9A5 PLEKHG4 LOC105369155 FHOD1 TRADD LRRC29 KIAA0895L C16orf70 ELMO3 FBXL8
nsv952044	Chr.16:67141198 - 67244397 on Build GRCh38	Deletion	E2F4 B3GNT9 MIR328 TMEM208 EXOC3L1 HSF4 NOL3 LOC105369155 FHOD1 TRADD LRRC29 KIAA0895L C16orf70 ELMO3 FBXL8
nsv1160429	Chr.16:67161549 - 67220197 on Build GRCh38	Deletion	E2F4 MIR328 LOC105369155 EXOC3L1 HSF4 LRRC29 KIAA0895L NOL3 ELMO3 FBXL8
nsv457513	Chr.16:67181417 - 67282697 on Build GRCh38	Loss	E2F4 MIR328 TMEM208 SLC9A5 PLEKHG4 LOC105369155 EXOC3L1 FHOD1 LRRC29 KIAA0895L ELMO3
nsv524492	Chr.16:67174030 - 67294550 on Build GRCh38	Loss	E2F4 MIR328 TMEM208 KCTD19 EXOC3L1 NOL3 SLC9A5 PLEKHG4 LOC105369155 FHOD1 LRRC29 KIAA0895L ELMO3
nsv524363	Chr.16:67136529 - 68071571 on Build GRCh38	Loss	E2F4 FAM65A EXOC3L1 LCAT AGRP TSNAXIP1 DPEP2 CENPT THAP11 LOC105369155 KIAA0895L C16orf86 LOC107984813 CARMIL2 MIR328 KCTD19 HSF4 LRRC36 PARD6A SLC9A5 NRN1L FHOD1 LRRC29 C16orf70 RANBP10 DPEP3 TPPP3 EDC4 ELMO3 CTCF TMEM208 DDX28 ATP6V0D1 PSMB10 LOC100505942 ZDHHC1 PSKH1 SLC12A4 B3GNT9 ENKD1 DUS2 CTRL NUTF2 NOL3 LOC100131303 GFOD2 HSD11B2 ACD PLEKHG4 TRADD FBXL8

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

RNA metabolism protein, nucleic acid metabolism protein, general transcription factor

Gene Ontology Categories:

Process(es)

regulation of transcription involved in G1/S transition of mitotic cell cycle
epithelial cell development
transcription from RNA polymerase II promoter
cell volume homeostasis
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
blood circulation
organ morphogenesis
regulation of cell proliferation
motile cilium assembly
positive regulation of transcription from RNA polymerase II promoter
centriole assembly
multi-ciliated epithelial cell differentiation

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
protein domain specific binding
promoter-specific chromatin binding