Hs03060824_cn

• Gene Symbol: ALKBH4
• Assay Reference Genome Location: Chr.7:102457374 on build GRCh38
• Cytoband: 7q22.1

Target Gene Details

• Entrez Gene ID: 54784
• Gene Name: alkB homolog 4, lysine demethylase
• Gene Aliases: ABH4
• Location: Chr.7:102456220-102464874 on Build GRCh38
• Assay Gene Location: Within Exon 3

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ALKBH4	NM_017621.3	3	967	NP_060091.1
	XM_005250464.2	3	860	XP_005250521.1
	XM_005250465.2	3	946	XP_005250522.1
	AK000020.1	3	954	BAA90888.1
	AK026097.1	3	865	BAB15358.1
	AK222689.1	3	956	BAD96409.1
	BC002820.2	3	934	AAH02820.1
	BC017096.1	3	934	AAH17096.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv831083	Chr.7:102340560 - 102655422 on Build GRCh38	Loss	ORAI2 MIR4467 RASA4B UPK3BL LOC107983993 MIR5090 PRKRIP1 LOC100289561 POLR2J2 LOC100630923 MIR548O SPDYE6 RASA4 POLR2J POLR2J3 SPDYE2 LRWD1 ALKBH4 LOC102724229 SPDYE2B
nsv8192	Chr.7:102450605 - 102692752 on Build GRCh38	Gain	ORAI2 MIR4467 RASA4B UPK3BL LOC107983993 MIR5090 POLR2J2 RASA4 POLR2J POLR2J3 SPDYE2 LRWD1 ALKBH4 LOC102724229 SPDYE2B
nsv428182	Chr.7:102257460 - 102735503 on Build GRCh38	Gain	ORAI2 MIR4467 CUX1 RASA4B UPK3BL LOC107983993 MIR5090 PRKRIP1 FBXL13 SH2B2 MIR4285 LOC100289561 POLR2J2 LOC100630923 MIR548O SPDYE6 RASA4 POLR2J POLR2J3 SPDYE2 LRWD1 ALKBH4 LOC102724229 SPDYE2B
dgv6538n100	Chr.7:102171110 - 103063688 on Build GRCh38	Gain	FAM185A RASA4B PRKRIP1 LRRC17 MIR4285 LOC100289561 POLR2J2 LOC100630923 MIR548O SPDYE6 NFE4 RASA4 POLR2J POLR2J3 SPDYE2 LRWD1 LOC102724229 SPDYE2B ORAI2 MIR4467 CUX1 UPK3BL LOC107983993 MIR5090 FBXL13 SH2B2 ALKBH4
nsv607998	Chr.7:102385213 - 102473462 on Build GRCh38	Gain+Loss	ORAI2 LOC100630923 MIR4467 MIR548O POLR2J LRWD1 ALKBH4 MIR5090 PRKRIP1
nsv5879	Chr.7:102450321 - 102747356 on Build GRCh38	Deletion	ORAI2 MIR4467 RASA4B UPK3BL LOC107983993 MIR5090 FBXL13 POLR2J2 RASA4 POLR2J POLR2J3 SPDYE2 LRWD1 ALKBH4 LOC102724229 SPDYE2B
nsv607999	Chr.7:102451288 - 102473452 on Build GRCh38	Loss	ORAI2 MIR4467 POLR2J LRWD1 ALKBH4 MIR5090

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

oxidoreductase, oxygenase, metabolite interconversion enzyme

Gene Ontology Categories:

Process(es)

transcription, DNA-templated
regulation of transcription, DNA-templated
protein demethylation
actomyosin structure organization
cleavage furrow ingression
oxidation-reduction process

Function(s)

actin binding
protein binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
demethylase activity
metal ion binding