Hs03349587_cn

• Gene Symbol: WNT3A
• Assay Reference Genome Location: Chr.1:228012145 on build GRCh38
• Cytoband: 1q42.13

Target Gene Details

• Entrez Gene ID: 89780
• Gene Name: Wnt family member 3A
• Gene Aliases: -
• Location: Chr.1:228007022-228067113 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
WNT3A	NM_033131.3			NP_149122.1
	XM_011544319.2			XP_011542621.1
	AB060284.1			BAB61052.1
	AK056278.1			BAB71136.1
	BC103921.1			AAI03922.1
	BC103922.2			AAI03923.1
	BC103923.1			AAI03924.1
	DA742143.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv826908	Chr.1:227707685 - 228503399 on Build GRCh38	Gain	MIR6742 LOC105373289 LOC101927401 MIR3620 GUK1 WNT3A C1orf35 HIST3H3 IBA57-AS1 HIST3H2BB MIR5008 WNT9A MRPL55 TRIM11 LOC100506571 ARF1 SNAP47 HIST3H2A LOC107985355 C1orf145 GJC2 MIR4666A IBA57 OBSCN PRSS38 LOC101060022 RNF187 JMJD4 TRIM17
nsv832803	Chr.1:227967417 - 228125980 on Build GRCh38	Loss	WNT3A C1orf35 LOC107985355 MRPL55 LOC100506571 MIR3620 ARF1 LOC101060022
esv32853	Chr.1:227692415 - 228670462 on Build GRCh38	Gain	LOC105373289 RNA5S11 HIST3H3 IBA57-AS1 HIST3H2BB LOC105373132 RNA5S10 RNA5S2 RNA5S15 WNT9A RNA5S5 MRPL55 RNA5S8 ARF1 SNAP47 GJC2 RHOU RNF187 JMJD4 MIR6742 LOC101927401 DUSP5P1 RNA5S6 RNA5S1 MIR3620 GUK1 WNT3A C1orf35 RNA5S14 RNA5S4 RNA5S16 RNA5S12 RNA5S3 MIR5008 RNA5S9 RNA5S7 BTNL10 TRIM11 LOC100506571 RNA5S13 HIST3H2A LOC107985355 C1orf145 MIR4666A RNA5S17 IBA57 OBSCN PRSS38 LOC101060022 TRIM17
nsv523935	Chr.1:227850423 - 228494048 on Build GRCh38	Loss	MIR6742 LOC101927401 MIR3620 GUK1 WNT3A C1orf35 HIST3H3 IBA57-AS1 HIST3H2BB MIR5008 WNT9A MRPL55 TRIM11 LOC100506571 ARF1 HIST3H2A LOC107985355 C1orf145 GJC2 MIR4666A IBA57 OBSCN LOC101060022 RNF187 TRIM17
nsv516409	Chr.1:227847430 - 228109044 on Build GRCh38	Loss	WNT3A C1orf35 LOC107985355 MIR5008 WNT9A MRPL55 LOC100506571 MIR3620 ARF1 LOC101060022
nsv952134	Chr.1:228000700 - 228021699 on Build GRCh38	Deletion	WNT3A

More Information

Additional Information:

For this assay, SNP(s) [rs73110733] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

intercellular signal molecule

Gene Ontology Categories:

Process(es)

osteoblast differentiation
in utero embryonic development
positive regulation of cytokine production
positive regulation of protein phosphorylation
heart looping
positive regulation of receptor internalization
negative regulation of heart induction by canonical Wnt signaling pathway
axon guidance
synapse assembly
positive regulation of cell proliferation
COP9 signalosome assembly
negative regulation of neuron projection development
Wnt signaling pathway
spinal cord association neuron differentiation
hippocampus development
cell proliferation in forebrain
Wnt signaling pathway involved in forebrain neuroblast division
dorsal/ventral neural tube patterning
hemopoiesis
neuron differentiation
extracellular matrix organization
mammary gland development
positive regulation of B cell proliferation
positive regulation of protein binding
positive regulation of peptidyl-serine phosphorylation
cell proliferation in midbrain
cellular protein localization
positive regulation of catenin import into nucleus
skeletal muscle cell differentiation
post-anal tail morphogenesis
synaptic vesicle recycling
inner ear morphogenesis
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of fat cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of mesodermal cell fate specification
paraxial mesodermal cell fate commitment
positive regulation of skeletal muscle tissue development
positive regulation of collateral sprouting in absence of injury
negative regulation of axon extension involved in axon guidance
negative regulation of neurogenesis
positive regulation of sequence-specific DNA binding transcription factor activity
palate development
canonical Wnt signaling pathway
positive regulation of protein tyrosine kinase activity
positive regulation of dermatome development
canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
regulation of microtubule cytoskeleton organization
platelet aggregation
cellular response to retinoic acid
axis elongation involved in somitogenesis
positive regulation of canonical Wnt signaling pathway
positive regulation of protein localization to plasma membrane
negative regulation of dopaminergic neuron differentiation
beta-catenin destruction complex disassembly
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
positive regulation of cell-cell adhesion mediated by cadherin
positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation
positive regulation of neural precursor cell proliferation
positive regulation of hepatocyte proliferation
positive regulation of transcription regulatory region DNA binding
positive regulation of cardiac muscle cell differentiation

Function(s)

transcription coactivator activity
receptor binding
frizzled binding
frizzled-2 binding
protein binding
protein domain specific binding
co-receptor binding
receptor agonist activity