Hs03461306_cn

• Gene Symbol: DVL3
• Assay Reference Genome Location: Chr.3:184156390 on build GRCh38
• Cytoband: 3q27.1

Target Gene Details

• Entrez Gene ID: 1857
• Gene Name: dishevelled segment polarity protein 3
• Gene Aliases: DRS3
• Location: Chr.3:184155311-184173614 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
DVL3	NM_004423.3			NP_004414.3
	XM_005247172.2			XP_005247229.1
	AF006013.1			AAB65244.1
	AK304686.1
	BC032459.1			AAH32459.1
	D86963.1			BAA13199.2
	U49262.1			AAB47447.1
	U75651.1			AAB84228.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv965241	Chr.3:184149752 - 184157260 on Build GRCh38	Duplication	DVL3
nsv829812	Chr.3:184136655 - 184302302 on Build GRCh38	Loss	ECE2 VWA5B2 ALG3 EIF2B5 DVL3 CAMK2N2 ABCF3 MIR1224 PSMD2 AP2M1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

positive regulation of protein phosphorylation
outflow tract septum morphogenesis
Wnt signaling pathway
intracellular signal transduction
non-canonical Wnt signaling pathway
non-canonical Wnt signaling pathway via JNK cascade
response to drug
positive regulation of JUN kinase activity
positive regulation of GTPase activity
positive regulation of transcription, DNA-templated
protein stabilization
canonical Wnt signaling pathway
Wnt signaling pathway, planar cell polarity pathway
negative regulation of canonical Wnt signaling pathway
cochlea morphogenesis
planar cell polarity pathway involved in neural tube closure
regulation of cellular protein localization
beta-catenin destruction complex disassembly

Function(s)

protease binding
receptor binding
frizzled binding
protein binding
beta-catenin binding
protein binding, bridging
protein heterodimerization activity
Rac GTPase binding