Hs03467604_cn

• Gene Symbol: NEK4
• Assay Reference Genome Location: Chr.3:52742134 on build GRCh38
• Cytoband: 3p21.1

Target Gene Details

• Entrez Gene ID: 6787
• Gene Name: NIMA related kinase 4
• Gene Aliases: NRK2, STK2, pp12301
• Location: Chr.3:52707936-52770949 on Build GRCh38
• Assay Gene Location: Within Exon 13

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NEK4	NM_001193533.1			NP_001180462.1
	NM_003157.4			NP_003148.2
	XM_006713310.2			XP_006713373.1
	XM_011534039.2			XP_011532341.1
	XM_011534040.2	13	2488	XP_011532342.1
	XM_017007085.1			XP_016862574.1
	XM_017007086.1			XP_016862575.1
	AK294165.1
	AK312420.1
	BC063044.1			AAH63044.1
	EF560744.1
	KJ592714.1
	L20321.1			AAA36658.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv508219	Chr.3:52707177 - 52769883 on Build GRCh38	Deletion	NEK4 SPCS1
esv2762328	Chr.3:52740868 - 52968134 on Build GRCh38	Loss	TMEM110 ITIH4 ITIH1 MUSTN1 ITIH3 SFMBT1 NEK4 ITIH4-AS1 MIR8064 TMEM110-MUSTN1
nsv834698	Chr.3:52715967 - 52894203 on Build GRCh38	Gain	TMEM110 ITIH4 ITIH1 MUSTN1 ITIH3 NEK4 ITIH4-AS1 MIR8064 TMEM110-MUSTN1

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Gene Ontology Categories:

Process(es)

mitotic cell cycle
protein phosphorylation
cellular response to DNA damage stimulus
mitotic nuclear division
signal transduction by protein phosphorylation
positive regulation of transcription, DNA-templated
cell division
regulation of replicative cell aging
regulation of cellular senescence
regulation of response to DNA damage stimulus

Function(s)

protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
ATP binding
manganese ion binding