Hs03668614_cn

• Gene Symbol: LYN
• Assay Reference Genome Location: Chr.8:55878183 on build GRCh38
• Cytoband: 8q12.1

Target Gene Details

• Entrez Gene ID: 4067
• Gene Name: LYN proto-oncogene, Src family tyrosine kinase
• Gene Aliases: JTK8, p53Lyn, p56Lyn
• Location: Chr.8:55877305-56012447 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
LYN	XM_011517529.2	1	879	XP_011515831.1
	XM_017013415.1	1	879	XP_016868904.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3617285	Chr.8:55864913 - 55911860 on Build GRCh38	Gain	LYN
dgv889n27	Chr.8:55799154 - 55963660 on Build GRCh38	Gain	TGS1 LYN
esv3617283	Chr.8:55804919 - 55968939 on Build GRCh38	Gain	TGS1 LYN
dgv459n21	Chr.8:55676869 - 56030580 on Build GRCh38	Gain	TMEM68 TGS1 LYN
esv3891398	Chr.8:55878090 - 56029138 on Build GRCh38	Gain	LYN
esv2752257	Chr.8:55867087 - 55969887 on Build GRCh38	Gain	LYN
nsv527341	Chr.8:55679732 - 55895699 on Build GRCh38	Gain	TMEM68 TGS1 LYN
dgv7228n100	Chr.8:55806899 - 55964201 on Build GRCh38	Gain	TGS1 LYN
dgv12173n54	Chr.8:55794435 - 55963660 on Build GRCh38	Gain	TGS1 LYN
nsv611393	Chr.8:55763923 - 55993509 on Build GRCh38	Gain	TMEM68 TGS1 LYN
nsv611392	Chr.8:55741553 - 55878302 on Build GRCh38	Gain	TMEM68 TGS1 LYN

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Gene Ontology Categories:

Process(es)

B cell homeostasis
regulation of cytokine production
regulation of protein phosphorylation
negative regulation of protein phosphorylation
stimulatory C-type lectin receptor signaling pathway
adaptive immune response
Fc receptor mediated stimulatory signaling pathway
tolerance induction to self antigen
histamine secretion by mast cell
platelet degranulation
negative regulation of myeloid leukocyte differentiation
immune response-regulating cell surface receptor signaling pathway
Fc receptor mediated inhibitory signaling pathway
regulation of B cell apoptotic process
protein phosphorylation
inflammatory response
cellular response to DNA damage stimulus
response to sterol depletion
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
central nervous system development
blood coagulation
positive regulation of cell proliferation
negative regulation of cell proliferation
response to toxic substance
response to hormone
response to carbohydrate
positive regulation of neuron projection development
oligodendrocyte development
response to organic cyclic compound
viral process
peptidyl-tyrosine phosphorylation
signal transduction by protein phosphorylation
platelet activation
erythrocyte differentiation
positive regulation of cell migration
negative regulation of B cell proliferation
neuron projection development
T cell costimulation
lipopolysaccharide-mediated signaling pathway
cellular response to extracellular stimulus
response to insulin
regulation of mast cell activation
regulation of cell adhesion mediated by integrin
negative regulation of toll-like receptor 2 signaling pathway
negative regulation of toll-like receptor 4 signaling pathway
cellular response to heat
peptidyl-tyrosine autophosphorylation
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
response to drug
positive regulation of tyrosine phosphorylation of STAT protein
response to amino acid
regulation of mast cell degranulation
negative regulation of MAP kinase activity
positive regulation of phosphatidylinositol 3-kinase activity
innate immune response
regulation of erythrocyte differentiation
protein autophosphorylation
ephrin receptor signaling pathway
response to axon injury
cytokine secretion
regulation of cytokine secretion
regulation of inflammatory response
negative regulation of immune response
B cell receptor signaling pathway
regulation of B cell receptor signaling pathway
positive regulation of B cell receptor signaling pathway
leukocyte migration
positive regulation of cellular component movement
regulation of release of sequestered calcium ion into cytosol
positive regulation of glial cell proliferation
positive regulation of Fc receptor mediated stimulatory signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
positive regulation of stress-activated protein kinase signaling cascade
regulation of ERK1 and ERK2 cascade
negative regulation of ERK1 and ERK2 cascade
positive regulation of oligodendrocyte progenitor proliferation
negative regulation of mast cell proliferation
positive regulation of mast cell proliferation
cellular response to retinoic acid
regulation of monocyte chemotaxis
regulation of platelet aggregation
dendritic cell differentiation
negative regulation of intracellular signal transduction
positive regulation of dendritic cell apoptotic process

Function(s)

protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor signaling protein tyrosine kinase activity
receptor binding
platelet-derived growth factor receptor binding
integrin binding
protein binding
ATP binding
SH3 domain binding
ubiquitin protein ligase binding
gamma-tubulin binding
glycosphingolipid binding
ion channel binding
phosphoprotein binding