Hs03673241_cn

• Gene Symbol: HSF1
• Assay Reference Genome Location: Chr.8:144292387 on build GRCh38
• Cytoband: 8q24.3

Target Gene Details

• Entrez Gene ID: 3297
• Gene Name: heat shock transcription factor 1
• Gene Aliases: HSTF1
• Location: Chr.8:144291588-144314722 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
HSF1	NM_005526.2			NP_005517.1
	XM_005272315.2			XP_005272372.1
	XM_005272316.2			XP_005272373.1
	XM_005272317.1			XP_005272374.1
	XM_017013377.1			XP_016868866.1
	AK222497.1			BAD96217.1
	AK290975.1
	BC014638.1			AAH14638.1
	BT007351.1			AAP36015.1
	DA481620.1
	M64673.1			AAA52695.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv12434n54	Chr.8:144270080 - 144516801 on Build GRCh38	Loss	CPSF1 GPT LOC101928953 CYHR1 DGAT1 PPP1R16A SLC39A4 ADCK5 MIR6848 MIR6893 TONSL-AS1 MFSD3 VPS28 BOP1 MIR6849 FBXL6 HSF1 TONSL TMEM249 SLC52A2 SCRT1 FOXH1 MIR1234 KIFC2 RECQL4 LOC101928902 MIR939
nsv470249	Chr.8:143889098 - 144519234 on Build GRCh38	Loss	CPSF1 MAF1 GPT LOC101928953 WDR97 CYHR1 DGAT1 PLEC PPP1R16A SLC39A4 CYC1 ADCK5 MIR6848 MIR6893 GPAA1 EXOSC4 MIR6846 TONSL-AS1 MFSD3 MIR6847 PARP10 VPS28 BOP1 SMPD5 MIR6849 FBXL6 SHARPIN HSF1 MIR7112 MROH1 TONSL MIR661 TMEM249 OPLAH SLC52A2 SCRT1 FOXH1 MIR1234 KIFC2 RECQL4 SCX SPATC1 LOC101928902 HGH1 GRINA LRRC14 MIR939
nsv515809	Chr.8:143904439 - 144519234 on Build GRCh38	Gain+Loss	CPSF1 MAF1 GPT LOC101928953 WDR97 CYHR1 DGAT1 PLEC PPP1R16A SLC39A4 CYC1 ADCK5 MIR6848 MIR6893 GPAA1 EXOSC4 MIR6846 TONSL-AS1 MFSD3 MIR6847 PARP10 VPS28 BOP1 SMPD5 MIR6849 FBXL6 SHARPIN HSF1 MIR7112 MROH1 TONSL MIR661 TMEM249 OPLAH SLC52A2 SCRT1 FOXH1 MIR1234 KIFC2 RECQL4 SCX SPATC1 LOC101928902 HGH1 GRINA LRRC14 MIR939
nsv824804	Chr.8:144289781 - 144339122 on Build GRCh38	Gain	HSF1 MIR6848 DGAT1 BOP1 SCRT1
nsv1025071	Chr.8:144044224 - 144300847 on Build GRCh38	Gain	HSF1 MIR7112 MROH1 MAF1 WDR97 OPLAH CYC1 SCX SPATC1 GPAA1 EXOSC4 MIR6846 HGH1 MIR6847 BOP1 SMPD5 SHARPIN
nsv428208	Chr.8:144041826 - 144722291 on Build GRCh38	Gain	CPSF1 MAF1 GPT LOC101928953 WDR97 CYHR1 LRRC24 DGAT1 PPP1R16A ARHGAP39 SLC39A4 CYC1 ADCK5 MIR6848 MIR6893 GPAA1 EXOSC4 MIR6846 TONSL-AS1 MFSD3 MIR6847 VPS28 BOP1 SMPD5 MIR6849 FBXL6 C8orf82 SHARPIN HSF1 MIR7112 MROH1 TONSL TMEM249 OPLAH ZNF251 SLC52A2 SCRT1 FOXH1 MIR1234 KIFC2 RECQL4 SCX SPATC1 LOC101928902 HGH1 LRRC14 MIR939

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

winged helix/forkhead transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
embryonic placenta development
protein phosphorylation
defense response
female meiotic division
spermatogenesis
negative regulation of cell proliferation
mRNA transcription
response to lipopolysaccharide
negative regulation of tumor necrosis factor production
cellular response to heat
positive regulation of multicellular organism growth
positive regulation of transcription from RNA polymerase II promoter
embryonic process involved in female pregnancy
regulation of cellular response to heat

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding