Hs03674525_cn

• Gene Symbol: PARP10
• Assay Reference Genome Location: Chr.8:143981135 on build GRCh38
• Cytoband: 8q24.3

Target Gene Details

• Entrez Gene ID: 84875
• Gene Name: poly(ADP-ribose) polymerase family member 10
• Gene Aliases: ARTD10
• Location: Chr.8:143977152-143986471 on Build GRCh38
• Assay Gene Location: Within Intron 8

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PARP10	NM_001317895.1			NP_001304824.1
	NM_032789.4			NP_116178.2
	NR_134234.1
	XM_011517336.2			XP_011515638.1
	AK027370.1			BAB55067.1
	AK075250.1			BAC11498.1
	AK124017.1
	AK128537.1
	AK129821.1
	AK222914.1			BAD96634.1
	AK303317.1
	BC014229.2			AAH14229.2
	BC019030.2			AAH19030.2
	BC132961.1
	BC136542.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv6445	Chr.8:143961415 - 143994522 on Build GRCh38	Insertion	PARP10 PLEC GRINA
esv2738046	Chr.8:143980764 - 143981685 on Build GRCh38	Deletion	PARP10
nsv470249	Chr.8:143889098 - 144519234 on Build GRCh38	Loss	MIR6849 SMPD5 MFSD3 TONSL OPLAH MIR1234 WDR97 RECQL4 SLC39A4 HGH1 EXOSC4 ADCK5 LOC101928902 BOP1 GPAA1 SCRT1 CYHR1 KIFC2 LRRC14 MIR6848 MAF1 SCX SLC52A2 DGAT1 GPT PPP1R16A TONSL-AS1 MIR6846 SHARPIN FBXL6 MROH1 CPSF1 TMEM249 PLEC FOXH1 LOC101928953 MIR7112 HSF1 MIR661 VPS28 CYC1 MIR6847 MIR6893 PARP10 MIR939 SPATC1 GRINA
nsv515809	Chr.8:143904439 - 144519234 on Build GRCh38	Gain+Loss	MIR6849 SMPD5 MFSD3 TONSL OPLAH MIR1234 WDR97 RECQL4 SLC39A4 HGH1 EXOSC4 ADCK5 LOC101928902 BOP1 GPAA1 SCRT1 CYHR1 KIFC2 LRRC14 MIR6848 MAF1 SCX SLC52A2 DGAT1 GPT PPP1R16A TONSL-AS1 MIR6846 SHARPIN FBXL6 MROH1 CPSF1 TMEM249 PLEC FOXH1 LOC101928953 MIR7112 HSF1 MIR661 VPS28 CYC1 MIR6847 MIR6893 PARP10 MIR939 SPATC1 GRINA
nsv612914	Chr.8:143972494 - 144120626 on Build GRCh38	Loss	SMPD5 OPLAH WDR97 EXOSC4 MIR6846 SHARPIN PLEC GPAA1 CYC1 MIR6847 PARP10 MAF1 SPATC1 GRINA
dgv12431n54	Chr.8:143845100 - 144161320 on Build GRCh38	Loss	SMPD5 OPLAH WDR97 HGH1 EXOSC4 MIR6846 SHARPIN MROH1 PLEC EPPK1 GPAA1 MIR661 CYC1 MIR6847 PARP10 MAF1 SPATC1 GRINA
nsv950015	Chr.8:143866633 - 144125597 on Build GRCh38	Deletion	SMPD5 OPLAH WDR97 EXOSC4 MIR6846 SHARPIN PLEC EPPK1 GPAA1 MIR661 CYC1 MIR6847 PARP10 MAF1 SPATC1 GRINA
nsv1161815	Chr.8:143775169 - 144080674 on Build GRCh38	Deletion	MIR6845 SMPD5 PUF60 NRBP2 OPLAH EXOSC4 MIR6846 MIR937 SCRIB PLEC EPPK1 LOC642574 MIR661 MIR6847 PARP10 SPATC1 GRINA
nsv470250	Chr.8:143917934 - 144097007 on Build GRCh38	Gain	SMPD5 GPAA1 OPLAH MIR661 CYC1 MIR6847 EXOSC4 MIR6846 PARP10 SPATC1 PLEC GRINA
dgv12433n54	Chr.8:143902404 - 144120626 on Build GRCh38	Gain	SMPD5 OPLAH WDR97 EXOSC4 MIR6846 SHARPIN PLEC GPAA1 MIR661 CYC1 MIR6847 PARP10 MAF1 SPATC1 GRINA
nsv612906	Chr.8:143917935 - 144090784 on Build GRCh38	Loss	SMPD5 GPAA1 OPLAH MIR661 MIR6847 EXOSC4 MIR6846 PARP10 SPATC1 PLEC GRINA

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

protein ADP-ribosylation
negative regulation of gene expression
regulation of chromatin assembly
negative regulation of NF-kappaB transcription factor activity
negative regulation of protein import into nucleus, translocation
negative regulation of viral genome replication
negative regulation of fibroblast proliferation
protein poly-ADP-ribosylation
protein auto-ADP-ribosylation
negative regulation of protein K63-linked ubiquitination

Function(s)

NAD+ ADP-ribosyltransferase activity
protein binding
K63-linked polyubiquitin binding