Hs03684629_cn

• Gene Symbol: PARP10
• Assay Reference Genome Location: Chr.8:143980753 on build GRCh38
• Cytoband: 8q24.3

Target Gene Details

• Entrez Gene ID: 84875
• Gene Name: poly(ADP-ribose) polymerase family member 10
• Gene Aliases: ARTD10
• Location: Chr.8:143977152-143986471 on Build GRCh38
• Assay Gene Location: Within Intron 8

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PARP10	NM_001317895.1			NP_001304824.1
	NM_032789.4			NP_116178.2
	NR_134234.1
	XM_011517336.2			XP_011515638.1
	AK027370.1			BAB55067.1
	AK075250.1			BAC11498.1
	AK124017.1
	AK128537.1
	AK129821.1
	AK222914.1			BAD96634.1
	AK303317.1
	BC014229.2			AAH14229.2
	BC019030.2			AAH19030.2
	BC132961.1
	BC136542.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv6445	Chr.8:143961415 - 143994522 on Build GRCh38	Insertion	PLEC PARP10 GRINA
esv2738046	Chr.8:143980764 - 143981685 on Build GRCh38	Deletion	PARP10
nsv470249	Chr.8:143889098 - 144519234 on Build GRCh38	Loss	RECQL4 TONSL-AS1 MIR6847 MAF1 CPSF1 SLC39A4 PARP10 WDR97 CYHR1 MFSD3 SMPD5 MIR661 KIFC2 SCRT1 VPS28 FOXH1 OPLAH PPP1R16A DGAT1 PLEC SHARPIN GPAA1 MIR6893 MIR6848 MIR6849 MROH1 SLC52A2 SCX ADCK5 GPT LOC101928902 MIR6846 LOC101928953 HSF1 BOP1 EXOSC4 LRRC14 MIR7112 MIR1234 MIR939 HGH1 TONSL GRINA CYC1 SPATC1 TMEM249 FBXL6
nsv515809	Chr.8:143904439 - 144519234 on Build GRCh38	Gain+Loss	RECQL4 TONSL-AS1 MIR6847 MAF1 CPSF1 SLC39A4 PARP10 WDR97 CYHR1 MFSD3 SMPD5 MIR661 KIFC2 SCRT1 VPS28 FOXH1 OPLAH PPP1R16A DGAT1 PLEC SHARPIN GPAA1 MIR6893 MIR6848 MIR6849 MROH1 SLC52A2 SCX ADCK5 GPT LOC101928902 MIR6846 LOC101928953 HSF1 BOP1 EXOSC4 LRRC14 MIR7112 MIR1234 MIR939 HGH1 TONSL GRINA CYC1 SPATC1 TMEM249 FBXL6
nsv612914	Chr.8:143972494 - 144120626 on Build GRCh38	Loss	MIR6847 MAF1 MIR6846 PARP10 WDR97 SMPD5 OPLAH EXOSC4 PLEC SHARPIN GPAA1 GRINA CYC1 SPATC1
dgv12431n54	Chr.8:143845100 - 144161320 on Build GRCh38	Loss	MROH1 MIR6847 MAF1 MIR6846 PARP10 WDR97 SMPD5 EPPK1 MIR661 OPLAH EXOSC4 PLEC SHARPIN HGH1 GPAA1 GRINA CYC1 SPATC1
nsv950015	Chr.8:143866633 - 144125597 on Build GRCh38	Deletion	MIR6847 MAF1 MIR6846 PARP10 WDR97 SMPD5 EPPK1 MIR661 OPLAH EXOSC4 PLEC SHARPIN GPAA1 GRINA CYC1 SPATC1
nsv1161815	Chr.8:143775169 - 144080674 on Build GRCh38	Deletion	MIR937 MIR6845 PUF60 MIR6847 SCRIB MIR6846 PARP10 SMPD5 LOC642574 EPPK1 MIR661 OPLAH EXOSC4 PLEC NRBP2 GRINA SPATC1
nsv470250	Chr.8:143917934 - 144097007 on Build GRCh38	Gain	SMPD5 MIR661 OPLAH EXOSC4 MIR6847 PLEC MIR6846 PARP10 GPAA1 GRINA CYC1 SPATC1
dgv12433n54	Chr.8:143902404 - 144120626 on Build GRCh38	Gain	MIR6847 MAF1 MIR6846 PARP10 WDR97 SMPD5 MIR661 OPLAH EXOSC4 PLEC SHARPIN GPAA1 GRINA CYC1 SPATC1
nsv612906	Chr.8:143917935 - 144090784 on Build GRCh38	Loss	SMPD5 MIR661 OPLAH EXOSC4 MIR6847 PLEC MIR6846 PARP10 GPAA1 GRINA SPATC1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

protein ADP-ribosylation
negative regulation of gene expression
regulation of chromatin assembly
negative regulation of NF-kappaB transcription factor activity
negative regulation of protein import into nucleus, translocation
negative regulation of viral genome replication
negative regulation of fibroblast proliferation
protein poly-ADP-ribosylation
protein auto-ADP-ribosylation
negative regulation of protein K63-linked ubiquitination

Function(s)

NAD+ ADP-ribosyltransferase activity
protein binding
K63-linked polyubiquitin binding