Hs03704520_cn

• Gene Symbol: CD274
• Assay Reference Genome Location: Chr.9:5454146 on build GRCh38
• Cytoband: 9p24.1

Target Gene Details

• Entrez Gene ID: 29126
• Gene Name: CD274 molecule
• Gene Aliases: B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1
• Location: Chr.9:5450503-5470567 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
CD274	NM_001267706.1			NP_001254635.1
	NM_001314029.1			NP_001300958.1
	NM_014143.3			NP_054862.1
	NR_052005.1
	AF233516.1			AAG18508.1
	AK300470.1
	AK314567.1
	BC069381.1			AAH69381.1
	DB160805.1
	DQ836393.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2759660	Chr.9:5288908 - 5454512 on Build GRCh38	Loss	LOC107987017 RLN1 PLGRKT CD274 RLN2
nsv613196	Chr.9:5345673 - 5514372 on Build GRCh38	Gain	LOC107987017 PLGRKT PDCD1LG2 CD274

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

immunoglobulin receptor superfamily

Gene Ontology Categories:

Process(es)

immune response
signal transduction
cell surface receptor signaling pathway
positive regulation of cell migration
T cell costimulation
negative regulation of interferon-gamma production
negative regulation of interleukin-10 production
response to cytokine
positive regulation of T cell proliferation
regulation of activated T cell proliferation
negative regulation of activated T cell proliferation
regulation of T cell apoptotic process
toxin transport
negative regulation of tumor necrosis factor superfamily cytokine production
positive regulation of interleukin-10 secretion

Function(s)

protein binding