Hs03717348_cn

• Gene Symbol: RXRA
• Assay Reference Genome Location: Chr.9:134327412 on build GRCh38
• Cytoband: 9q34.2

Target Gene Details

• Entrez Gene ID: 6256
• Gene Name: retinoid X receptor alpha
• Gene Aliases: NR2B1
• Location: Chr.9:134326463-134440586 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
RXRA	NM_002957.5			NP_002948.1
	AB307705.1
	AK090416.1			BAC03397.1
	BC063827.1			AAH63827.1
	BC110998.1			AAI10999.1
	BQ220698.1
	HQ692843.1
	X52773.1			CAA36982.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1075687	Chr.9:134325053 - 134327854 on Build GRCh38	Deletion	RXRA
dgv7722n100	Chr.9:134261330 - 134467038 on Build GRCh38	Gain	MIR4669 RXRA
dgv7723n100	Chr.9:134309226 - 134469090 on Build GRCh38	Gain	MIR4669 RXRA
esv2739138	Chr.9:132727483 - 135521553 on Build GRCh38	Deletion	CELP MIR3689E DBH-AS1 DBH MIR4669 RNU6ATAC SNORD36A LOC101448202 MIR3689F VAV2 RALGDS LOC105376306 LOC401557 SPACA9 CACFD1 SARDH SNORD36C PPP1R26-AS1 MED22 SURF1 FCN1 WDR5 FAM163B MIR6877 REXO4 LINC00094 MIR3689C OBP2B MIR3689D1 C9orf116 RXRA STKLD1 SLC2A6 C9orf62 SNORD36B ADAMTS13 MRPS2 COL5A1 LOC100130548 SNORD24 ADAMTSL2 RPL7A BRD3 SURF4 LCN1 MIR3689B AK8 LOC101928525 OLFM1 SURF2 MIR548AW PPP1R26 GFI1B MIR3689A SNORD141A TSC1 FCN2 LOC101928193 GTF3C5 CEL ABO SURF6 COL5A1-AS1 MIR3689D2 LOC100996574 GBGT1 TMEM8C
nsv466634	Chr.9:134305392 - 134374858 on Build GRCh38	Loss	RXRA
nsv615804	Chr.9:134290253 - 134351537 on Build GRCh38	Loss	RXRA
nsv831750	Chr.9:134213606 - 134335327 on Build GRCh38	Gain+Loss	RXRA
nsv951809	Chr.9:134324255 - 134506754 on Build GRCh38	Deletion	MIR4669 RXRA
esv27796	Chr.9:134325883 - 134327485 on Build GRCh38	Loss	RXRA
nsv469908	Chr.9:134278568 - 134445511 on Build GRCh38	Loss	MIR4669 RXRA

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

C4 zinc finger nuclear receptor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
liver development
maternal placenta development
transcription initiation from RNA polymerase II promoter
vitamin metabolic process
inflammatory response
midgut development
embryo implantation
aging
cholesterol metabolic process
negative regulation of cell proliferation
response to selenium ion
bile acid and bile salt transport
modulation by virus of host morphology or physiology
axon regeneration
regulation of myelination
response to retinoic acid
cellular response to insulin stimulus
response to vitamin A
response to vitamin D
peroxisome proliferator activated receptor signaling pathway
camera-type eye development
positive regulation of apoptotic process
steroid hormone mediated signaling pathway
cellular lipid metabolic process
response to ethanol
positive regulation of transcription from RNA polymerase II promoter
positive regulation of translational initiation by iron
retinoic acid receptor signaling pathway
protein homotetramerization
response to glucocorticoid
ventricular cardiac muscle tissue morphogenesis
ventricular cardiac muscle cell differentiation
cardiac muscle cell proliferation
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
regulation of branching involved in prostate gland morphogenesis
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus

Function(s)

RNA polymerase II regulatory region sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
retinoic acid receptor activity
transcription coactivator activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
9-cis retinoic acid receptor activity
protein binding
zinc ion binding
enzyme binding
protein domain specific binding
chromatin DNA binding
protein complex binding
vitamin D receptor binding
retinoic acid receptor binding
sequence-specific DNA binding
transcription regulatory region DNA binding
retinoic acid-responsive element binding
protein heterodimerization activity
vitamin D response element binding