Hs03975973_cn

• Gene Symbol: CRK
• Assay Reference Genome Location: Chr.17:1433178 on build GRCh38
• Cytoband: 17p13.3

Target Gene Details

• Entrez Gene ID: 1398
• Gene Name: CRK proto-oncogene, adaptor protein
• Gene Aliases: CRKII, p38
• Location: Chr.17:1421353-1456267 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
CRK	NM_005206.4			NP_005197.3
	NM_016823.3			NP_058431.2
	AK291060.1
	BC001718.1			AAH01718.1
	BC008506.1			AAH08506.1
	BC009837.1			AAH09837.1
	BT007277.1			AAP35941.1
	D10656.1			BAA01505.1
	KU177996.1
	KU177997.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv833334	Chr.17:1411327 - 1582381 on Build GRCh38	Loss	SLC43A2 INPP5K MYO1C PITPNA-AS1 PITPNA CRK
esv3639685	Chr.17:1430039 - 1436256 on Build GRCh38	Loss	CRK
nsv470567	Chr.17:1391192 - 1463828 on Build GRCh38	Gain	YWHAE CRK
nsv1057782	Chr.17:1351585 - 1512616 on Build GRCh38	Gain	YWHAE INPP5K MYO1C CRK

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

activation of MAPKK activity
regulation of transcription from RNA polymerase II promoter
regulation of actin cytoskeleton organization
regulation of Rac protein signal transduction
Fc-gamma receptor signaling pathway involved in phagocytosis
regulation of GTPase activity
vascular endothelial growth factor receptor signaling pathway
ephrin receptor signaling pathway
positive regulation of substrate adhesion-dependent cell spreading

Function(s)

SH3/SH2 adaptor activity
protein binding
SH2 domain binding
protein phosphorylated amino acid binding
ephrin receptor binding