Hs04003845_cn

• Gene Symbol: PIAS2
• Assay Reference Genome Location: Chr.18:46834914 on build GRCh38
• Cytoband: 18q21.1

Target Gene Details

• Entrez Gene ID: 9063
• Gene Name: protein inhibitor of activated STAT 2
• Gene Aliases: ARIP3, DIP, MIZ, MIZ1, PIASX, PIASX-ALPHA, PIASX-BETA, SIZ2, ZMIZ4
• Location: Chr.18:46803224-46920167 on Build GRCh38
• Assay Gene Location: Within Intron 17

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PIAS2	NM_001324046.1			NP_001310975.1
	NM_001324047.1			NP_001310976.1
	NM_001324048.1			NP_001310977.1
	NM_001324049.1			NP_001310978.1
	NM_001324051.1			NP_001310980.1
	NM_001324052.1			NP_001310981.1
	NM_001324053.1			NP_001310982.1
	NM_001324054.1			NP_001310983.1
	NM_001324055.1			NP_001310984.1
	NM_001324057.1			NP_001310986.1
	NM_001324058.1			NP_001310987.1
	NM_001324059.1			NP_001310988.1
	NM_004671.4			NP_004662.2
	NM_173206.3			NP_775298.1
	NR_136684.1
	NR_136685.1
	XM_005258377.3			XP_005258434.1
	XM_005258379.3			XP_005258436.1
	XM_006722571.3			XP_006722634.1
	XM_006722572.3			XP_006722635.1
	XM_006722573.2			XP_006722636.1
	XM_011526258.2			XP_011524560.1
	XM_011526259.2			XP_011524561.1
	XM_017026068.1			XP_016881557.1
	XM_017026069.1			XP_016881558.1
	XM_017026070.1			XP_016881559.1
	XM_017026071.1			XP_016881560.1
	XM_017026072.1			XP_016881561.1
	AF077953.1			AAC36704.1
	AF077954.1			AAC36705.1
	AK294801.1
	AK308143.1
	BC015190.1			AAH15190.1
	BC111060.1			AAI11061.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv9629	Chr.18:46684730 - 47231140 on Build GRCh38	Gain+Loss	HDHD2 KATNAL2 SKOR2 TCEB3B IER3IP1 PIAS2 TCEB3CL ST8SIA5 TCEB3CL2 TCEB3C LOC107983955

More Information

Additional Information:

For this assay, SNP(s) [rs115158075] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

transcription, DNA-templated
protein sumoylation
androgen receptor signaling pathway
regulation of osteoblast differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of androgen receptor signaling pathway

Function(s)

DNA binding
transcription coactivator activity
protein binding
transcription factor binding
zinc ion binding
ligase activity
SUMO transferase activity
ubiquitin protein ligase binding
androgen receptor binding
SUMO ligase activity