Hs04013096_cn

• Gene Symbol: TLE2
• Assay Reference Genome Location: Chr.19:2998801 on build GRCh38
• Cytoband: 19p13.3

Target Gene Details

• Entrez Gene ID: 7089
• Gene Name: transducin like enhancer of split 2
• Gene Aliases: ESG, ESG2, GRG2
• Location: Chr.19:2997638-3047635 on Build GRCh38
• Assay Gene Location: Within Intron 22

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TLE2	NM_001144761.1			NP_001138233.1
	NM_001144762.1			NP_001138234.1
	NM_001300846.1			NP_001287775.1
	NM_003260.4			NP_003251.2
	XM_006722864.2			XP_006722927.1
	XM_011528230.1			XP_011526532.1
	AK123183.1
	AK293407.1
	AK293482.1
	AK308137.1
	AK312285.1
	BC017364.2			AAH17364.1
	M99436.1			AAA61193.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv833709	Chr.19:2950244 - 3068609 on Build GRCh38	Loss	TLE6 TLE2 AES
dgv47n68	Chr.19:2977776 - 3162121 on Build GRCh38	Loss	GNA11 LOC100996351 TLE6 TLE2 GNA15 AES

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

transcription cofactor

Gene Ontology Categories:

Process(es)

transcription, DNA-templated
signal transduction
organ morphogenesis
Wnt signaling pathway
negative regulation of transcription, DNA-templated
negative regulation of canonical Wnt signaling pathway
beta-catenin-TCF complex assembly

Function(s)

transcription corepressor activity
protein binding