Hs04023426_cn

• Gene Symbol: STK11
• Assay Reference Genome Location: Chr.19:1207769 on build GRCh38
• Cytoband: 19p13.3

Target Gene Details

• Entrez Gene ID: 6794
• Gene Name: serine/threonine kinase 11
• Gene Aliases: LKB1, PJS, hLKB1
• Location: Chr.19:1205799-1228435 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
STK11	NM_000455.4			NP_000446.1
	XM_005259617.2			XP_005259674.1
	XM_005259618.3			XP_005259675.1
	XM_011528209.1			XP_011526511.1
	AB209553.1			BAD92790.1
	AF035625.1			AAC39527.1
	AF217978.1			AAG17221.1
	AK314858.1
	BC007981.2			AAH07981.1
	BC019334.1			AAH19334.1
	EF644172.1
	KU178339.1
	KU178340.1
	U63333.1			AAB05809.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1058677	Chr.19:1054061 - 1283189 on Build GRCh38	Loss	CBARP POLR2E GPX4 EFNA2 C19orf24 MIDN ARHGAP45 CIRBP-AS1 CIRBP ATP5D SBNO2 ABCA7 LOC102725180 STK11
dgv136n111	Chr.19:1038223 - 1329640 on Build GRCh38	Deletion	CBARP POLR2E GPX4 EFNA2 C19orf24 MIDN ARHGAP45 CIRBP-AS1 CIRBP ATP5D SBNO2 ABCA7 CNN2 LOC102725180 STK11
nsv9662	Chr.19:893394 - 1317740 on Build GRCh38	Gain	CBARP POLR2E RNU6-9 GPX4 TMEM259 KISS1R EFNA2 C19orf24 MIDN WDR18 R3HDM4 ARHGAP45 LOC105372235 RNU6-2 CIRBP-AS1 GRIN3B CIRBP ATP5D SBNO2 ABCA7 CNN2 LOC102725180 STK11 ARID3A
nsv470104	Chr.19:1170446 - 1325151 on Build GRCh38	Loss	CBARP CIRBP ATP5D EFNA2 C19orf24 MIDN SBNO2 LOC102725180 CIRBP-AS1 STK11
nsv1160555	Chr.19:887275 - 1346084 on Build GRCh38	Deletion	CBARP POLR2E TMEM259 C19orf24 ARHGAP45 RNU6-2 CIRBP-AS1 GRIN3B CIRBP SBNO2 CNN2 LOC102725180 STK11 ARID3A RNU6-9 GPX4 KISS1R EFNA2 MIDN WDR18 R3HDM4 MED16 LOC105372235 ATP5D ABCA7
nsv953941	Chr.19:1205602 - 1322401 on Build GRCh38	Deletion	CBARP CIRBP ATP5D EFNA2 C19orf24 MIDN CIRBP-AS1 STK11
nsv470103	Chr.19:1086044 - 1325151 on Build GRCh38	Gain	CBARP POLR2E GPX4 EFNA2 C19orf24 MIDN ARHGAP45 CIRBP-AS1 CIRBP ATP5D SBNO2 LOC102725180 STK11
esv2758743	Chr.19:951641 - 1544934 on Build GRCh38	Gain+Loss	CBARP POLR2E C19orf25 TMEM259 C19orf24 PCSK4 ARHGAP45 RPS15 MUM1 RNU6-2 CIRBP-AS1 GRIN3B GAMT NDUFS7 DAZAP1 PLK5 CIRBP SBNO2 CNN2 LOC102725180 APC2 STK11 ADAMTSL5 ARID3A GPX4 EFNA2 MIDN WDR18 LOC105372235 ATP5D REEP6 ABCA7

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

regulation of cell growth
tissue homeostasis
vasculature development
protein phosphorylation
autophagy
cellular response to DNA damage stimulus
cell cycle arrest
spermatid development
axonogenesis
negative regulation of cell proliferation
response to ionizing radiation
positive regulation of autophagy
establishment of cell polarity
regulation of Wnt signaling pathway
negative regulation of cell growth
positive regulation of transforming growth factor beta receptor signaling pathway
activation of protein kinase activity
TCR signalosome assembly
glucose homeostasis
anoikis
positive thymic T cell selection
protein autophosphorylation
regulation of dendrite morphogenesis
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of axonogenesis
T cell receptor signaling pathway
negative regulation of lipid biosynthetic process
Golgi localization
regulation of protein kinase B signaling
canonical Wnt signaling pathway
negative regulation of epithelial cell proliferation involved in prostate gland development
cellular response to UV-B
positive regulation of protein serine/threonine kinase activity
intrinsic apoptotic signaling pathway by p53 class mediator
dendrite extension
positive regulation of protein localization to nucleus
regulation of signal transduction by p53 class mediator
negative regulation of TORC1 signaling

Function(s)

magnesium ion binding
p53 binding
protein serine/threonine kinase activity
protein binding
ATP binding
LRR domain binding
protein kinase activator activity