Hs04037241_cn

• Gene Symbol: TRIB3
• Assay Reference Genome Location: Chr.20:382941 on build GRCh38
• Cytoband: 20p13

Target Gene Details

• Entrez Gene ID: 57761
• Gene Name: tribbles pseudokinase 3
• Gene Aliases: C20orf97, NIPK, SINK, SKIP3, TRB3
• Location: Chr.20:380629-397559 on Build GRCh38
• Assay Gene Location: Within Intron 3

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TRIB3	NM_001301188.1			NP_001288117.1
	NM_001301190.1			NP_001288119.1
	NM_001301193.1			NP_001288122.1
	NM_001301196.1			NP_001288125.1
	NM_001301201.1			NP_001288130.1
	NM_021158.4			NP_066981.2
	XM_017027989.1			XP_016883478.1
	AJ697936.1			CAG27047.1
	AK026945.1			BAB15597.1
	AK222837.1			BAD96557.1
	AK297546.1
	AY247738.1			AAP04407.1
	BC019363.1			AAH19363.1
	BC027484.1			AAH27484.1
	BG828172.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3644950	Chr.20:378868 - 384473 on Build GRCh38	Loss	TRIB3
nsv1065287	Chr.20:361224 - 384103 on Build GRCh38	Loss	TRIB3
dgv773e199	Chr.20:378808 - 384510 on Build GRCh38	Deletion	TRIB3
nsv510777	Chr.20:366849 - 416704 on Build GRCh38	Deletion	TRIB3 RBCK1
nsv585170	Chr.20:380145 - 422066 on Build GRCh38	Loss	TRIB3 RBCK1
nsv585169	Chr.20:363435 - 384103 on Build GRCh38	Loss	TRIB3
dgv4219n100	Chr.20:80652 - 461103 on Build GRCh38	Gain	LOC101929937 DEFB126 SOX12 DEFB128 TRIB3 ZCCHC3 DEFB132 DEFB127 NRSN2 DEFB125 DEFB129 C20orf96 NRSN2-AS1 TBC1D20 RBCK1
esv3893263	Chr.20:216521 - 434561 on Build GRCh38	Loss	LOC101929937 NRSN2 SOX12 TRIB3 DEFB129 C20orf96 NRSN2-AS1 ZCCHC3 DEFB132 RBCK1

More Information

Additional Information:

For this assay, SNP(s) [rs76332187] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
protein phosphorylation
negative regulation of protein kinase activity
regulation of glucose transport
positive regulation of protein binding
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
cellular response to insulin stimulus
response to endoplasmic reticulum stress
regulation of MAP kinase activity
negative regulation of fat cell differentiation
negative regulation of fatty acid biosynthetic process
negative regulation of transcription, DNA-templated
positive regulation of ubiquitin-protein transferase activity
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Function(s)

transcription corepressor activity
protein kinase inhibitor activity
protein binding
ATP binding
kinase activity
protein kinase binding
mitogen-activated protein kinase kinase binding
ubiquitin protein ligase binding
ubiquitin-protein transferase regulator activity