Hs04071745_cn

• Gene Symbol: TPTE
• Assay Reference Genome Location: Chr.21:10568466 on build GRCh38
• Cytoband: 21p11.2

Target Gene Details

• Entrez Gene ID: 7179
• Gene Name: transmembrane phosphatase with tensin homology
• Gene Aliases: CT44, PTEN2
• Location: Chr.21:10521514-10606270 on Build GRCh38
• Assay Gene Location: Within Intron 11

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TPTE	NM_001290224.1			NP_001277153.1
	NM_199259.3			NP_954868.1
	NM_199260.3			NP_954869.1
	NM_199261.3			NP_954870.2
	AF007118.1			AAC34574.1
	AF495908.1			AAQ06674.1
	AK308254.1
	AK314285.1
	AL833345.1
	AY219886.1			AAP45143.1
	AY219887.1			AAP45144.1
	AY219888.1			AAP45145.1
	BC028719.1			AAH28719.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv4363n100	Chr.21:10420787 - 10576547 on Build GRCh38	Loss	TPTE BAGE2 LOC105378260
dgv4359n100	Chr.21:10551998 - 10601230 on Build GRCh38	Loss	TPTE
dgv712n67	Chr.21:10449897 - 10648466 on Build GRCh38	Gain	TPTE BAGE2 LOC105378260
dgv7734n54	Chr.21:10560297 - 10754646 on Build GRCh38	Loss	TPTE IGHV1OR21-1
dgv4350n100	Chr.21:10545409 - 10775598 on Build GRCh38	Loss	TPTE IGHV1OR21-1
dgv4361n100	Chr.21:10502083 - 10591182 on Build GRCh38	Loss	TPTE LOC105378260
dgv7728n54	Chr.21:10416793 - 10813996 on Build GRCh38	Gain	TPTE BAGE2 LOC105378260 IGHV1OR21-1
dgv2463e59	Chr.21:10565678 - 10578176 on Build GRCh38	Duplication	TPTE
nsv428382	Chr.21:10337224 - 10764692 on Build GRCh38	Gain+Loss	TPTE BAGE2 LOC105378260 IGHV1OR21-1
nsv1160693	Chr.21:10559033 - 10775586 on Build GRCh38	Duplication	TPTE IGHV1OR21-1
dgv7748n54	Chr.21:10507714 - 10657385 on Build GRCh38	Loss	TPTE LOC105378260 IGHV1OR21-1
esv32564	Chr.21:10336174 - 10647411 on Build GRCh38	Gain+Loss	TPTE BAGE2 LOC105378260
dgv4357n100	Chr.21:10548222 - 10611996 on Build GRCh38	Loss	TPTE
nsv819313	Chr.21:10564605 - 10648266 on Build GRCh38	Gain	TPTE
nsv9837	Chr.21:10524671 - 10660645 on Build GRCh38	Gain+Loss	TPTE IGHV1OR21-1
dgv711n67	Chr.21:10568256 - 10648466 on Build GRCh38	Gain	TPTE
dgv4356n100	Chr.21:10448879 - 10643715 on Build GRCh38	Loss	TPTE BAGE2 LOC105378260
esv3435572	Chr.21:10564478 - 10573076 on Build GRCh38	Duplication	TPTE
dgv4355n100	Chr.21:10338676 - 10775598 on Build GRCh38	Gain	TPTE BAGE2 LOC105378260 IGHV1OR21-1
nsv1059430	Chr.21:10558280 - 10643715 on Build GRCh38	Loss	TPTE
nsv586977	Chr.21:10515528 - 10599016 on Build GRCh38	Loss	TPTE
nsv1059477	Chr.21:10458823 - 10643715 on Build GRCh38	Gain	TPTE BAGE2 LOC105378260
dgv7731n54	Chr.21:10540506 - 10804226 on Build GRCh38	Loss	TPTE IGHV1OR21-1
nsv953331	Chr.21:10427057 - 10739656 on Build GRCh38	Duplication	TPTE BAGE2 LOC105378260 IGHV1OR21-1
dgv4351n100	Chr.21:10536307 - 10775598 on Build GRCh38	Gain	TPTE IGHV1OR21-1
dgv7737n54	Chr.21:10526466 - 10751106 on Build GRCh38	Loss	TPTE IGHV1OR21-1
nsv1059291	Chr.21:10348542 - 10775598 on Build GRCh38	Loss	TPTE BAGE2 LOC105378260 IGHV1OR21-1
nsv1147252	Chr.21:10522357 - 10741958 on Build GRCh38	Duplication	TPTE IGHV1OR21-1
esv29976	Chr.21:10345209 - 10646524 on Build GRCh38	Gain	TPTE BAGE2 LOC105378260
dgv4353n100	Chr.21:10458894 - 10775598 on Build GRCh38	Loss	TPTE BAGE2 LOC105378260 IGHV1OR21-1
esv1000174	Chr.21:10334703 - 10569121 on Build GRCh38	Deletion	TPTE BAGE2 LOC105378260
nsv437841	Chr.21:10326676 - 10605468 on Build GRCh38	Loss	TPTE BAGE2 LOC105378260
dgv7729n54	Chr.21:10324453 - 10813996 on Build GRCh38	Gain	TPTE BAGE2 LOC105378260 IGHV1OR21-1
dgv67n17	Chr.21:10539128 - 10595541 on Build GRCh38	Loss	TPTE
esv2763681	Chr.21:10336545 - 10775586 on Build GRCh38	Gain+Loss	TPTE BAGE2 LOC105378260 IGHV1OR21-1
dgv4362n100	Chr.21:10534998 - 10589451 on Build GRCh38	Loss	TPTE
esv2760696	Chr.21:10494350 - 10775586 on Build GRCh38	Gain+Loss	TPTE LOC105378260 IGHV1OR21-1
esv28756	Chr.21:10324359 - 10814516 on Build GRCh38	Gain+Loss	TPTE BAGE2 LOC105378260 IGHV1OR21-1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

protein phosphatase

Gene Ontology Categories:

Process(es)

protein dephosphorylation
signal transduction
peptidyl-tyrosine dephosphorylation

Function(s)

protein tyrosine phosphatase activity
protein tyrosine/serine/threonine phosphatase activity