Hs04079794_cn

• Gene Symbol: CRKL
• Assay Reference Genome Location: Chr.22:20930018 on build GRCh38
• Cytoband: 22q11.21

Target Gene Details

• Entrez Gene ID: 1399
• Gene Name: CRK like proto-oncogene, adaptor protein
• Gene Aliases: -
• Location: Chr.22:20917398-20953749 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
CRKL	NM_005207.3			NP_005198.1
	AK292909.1
	BC043500.1			AAH43500.1
	CR456423.1			CAG30309.1
	X59656.1			CAA42199.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3893441	Chr.22:20733858 - 21135629 on Build GRCh38	Gain+Loss	LOC101928891 SLC7A4 AIFM3 BCRP2 THAP7-AS1 PI4KA CRKL P2RX6P SNAP29 LZTR1 TUBA3FP THAP7 SERPIND1 P2RX6 MIR649 LRRC74B
nsv1065617	Chr.22:20705383 - 21111546 on Build GRCh38	Gain	LOC101928891 SLC7A4 AIFM3 BCRP2 THAP7-AS1 PI4KA CRKL P2RX6P SNAP29 LZTR1 TUBA3FP THAP7 SERPIND1 P2RX6 MIR649 LRRC74B
dgv7994n54	Chr.22:20559470 - 21111491 on Build GRCh38	Gain	LOC101928891 SLC7A4 AIFM3 BCRP2 THAP7-AS1 PI4KA CRKL MED15 P2RX6P SNAP29 LZTR1 SMPD4P1 TUBA3FP THAP7 SERPIND1 P2RX6 MIR649 LRRC74B TMEM191A POM121L4P
nsv834141	Chr.22:20859455 - 21051952 on Build GRCh38	Loss	LOC101928891 SLC7A4 AIFM3 THAP7-AS1 CRKL P2RX6P SNAP29 LZTR1 TUBA3FP THAP7 P2RX6 MIR649 LRRC74B
esv2763693	Chr.22:20581182 - 21111546 on Build GRCh38	Gain	LOC101928891 SLC7A4 AIFM3 BCRP2 THAP7-AS1 PI4KA CRKL MED15 P2RX6P SNAP29 LZTR1 SMPD4P1 TUBA3FP THAP7 SERPIND1 P2RX6 MIR649 LRRC74B TMEM191A POM121L4P
esv3647304	Chr.22:20902577 - 21081487 on Build GRCh38	Loss	LOC101928891 SLC7A4 AIFM3 LZTR1 TUBA3FP THAP7-AS1 THAP7 P2RX6 CRKL MIR649 LRRC74B P2RX6P
nsv588305	Chr.22:20721841 - 21108064 on Build GRCh38	Loss	LOC101928891 SLC7A4 AIFM3 BCRP2 THAP7-AS1 PI4KA CRKL P2RX6P SNAP29 LZTR1 TUBA3FP THAP7 SERPIND1 P2RX6 MIR649 LRRC74B
esv2678175	Chr.22:20691629 - 21284480 on Build GRCh38	Deletion	LOC101928891 SLC7A4 AIFM3 BCRP2 THAP7-AS1 GGT2 PI4KA POM121L8P CRKL P2RX6P SNAP29 LZTR1 TUBA3FP THAP7 SERPIND1 P2RX6 MIR649 FAM230B LRRC74B TMEM191A POM121L4P
dgv7993n54	Chr.22:20346736 - 21111491 on Build GRCh38	Gain	LOC101928891 AIFM3 THAP7-AS1 ZNF74 CRKL P2RX6P SNAP29 KLHL22 SERPIND1 P2RX6 TMEM191A LOC101927859 USP41 SLC7A4 BCRP2 PI4KA MED15 SCARF2 LZTR1 SMPD4P1 TUBA3FP THAP7 MIR649 LRRC74B POM121L4P
nsv834140	Chr.22:20742586 - 20951488 on Build GRCh38	Loss	PI4KA SERPIND1 CRKL SNAP29
dgv4483n100	Chr.22:20362634 - 21212930 on Build GRCh38	Gain	LOC101928891 AIFM3 THAP7-AS1 GGT2 ZNF74 CRKL P2RX6P SNAP29 KLHL22 SERPIND1 P2RX6 FAM230B TMEM191A USP41 SLC7A4 BCRP2 PI4KA MED15 SCARF2 LZTR1 SMPD4P1 TUBA3FP THAP7 MIR649 LRRC74B POM121L4P
nsv1066625	Chr.22:20920683 - 20948518 on Build GRCh38	Gain	CRKL
dgv4484n100	Chr.22:20928403 - 20948062 on Build GRCh38	Gain	CRKL
nsv523162	Chr.22:20389246 - 21108064 on Build GRCh38	Loss	LOC101928891 USP41 SLC7A4 AIFM3 BCRP2 THAP7-AS1 PI4KA ZNF74 CRKL MED15 P2RX6P SNAP29 SCARF2 KLHL22 LZTR1 SMPD4P1 TUBA3FP THAP7 SERPIND1 P2RX6 MIR649 LRRC74B TMEM191A POM121L4P

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

activation of MAPKK activity
blood vessel development
JNK cascade
Ras protein signal transduction
heart development
positive regulation of cell proliferation
organ morphogenesis
anterior/posterior pattern specification
intracellular signal transduction
thymus development
parathyroid gland development
cell-cell adhesion
positive regulation of substrate adhesion-dependent cell spreading

Function(s)

signal transducer activity
SH3/SH2 adaptor activity
protein binding
poly(A) RNA binding
cadherin binding involved in cell-cell adhesion