Hs04089019_cn

• Gene Symbol: CRKL
• Assay Reference Genome Location: Chr.22:20926257 on build GRCh38
• Cytoband: 22q11.21

Target Gene Details

• Entrez Gene ID: 1399
• Gene Name: CRK like proto-oncogene, adaptor protein
• Gene Aliases: -
• Location: Chr.22:20917398-20953749 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
CRKL	NM_005207.3			NP_005198.1
	AK292909.1
	BC043500.1			AAH43500.1
	CR456423.1			CAG30309.1
	X59656.1			CAA42199.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv7994n54	Chr.22:20559470 - 21111491 on Build GRCh38	Gain	TUBA3FP TMEM191A THAP7-AS1 SERPIND1 BCRP2 MED15 P2RX6 AIFM3 THAP7 CRKL MIR649 SLC7A4 POM121L4P SNAP29 LOC101928891 PI4KA SMPD4P1 LRRC74B P2RX6P LZTR1
esv3893441	Chr.22:20733858 - 21135629 on Build GRCh38	Gain+Loss	TUBA3FP THAP7-AS1 SERPIND1 BCRP2 P2RX6 AIFM3 THAP7 CRKL MIR649 SLC7A4 SNAP29 LOC101928891 PI4KA LRRC74B P2RX6P LZTR1
nsv1065617	Chr.22:20705383 - 21111546 on Build GRCh38	Gain	TUBA3FP THAP7-AS1 SERPIND1 BCRP2 P2RX6 AIFM3 THAP7 CRKL MIR649 SLC7A4 SNAP29 LOC101928891 PI4KA LRRC74B P2RX6P LZTR1
nsv834141	Chr.22:20859455 - 21051952 on Build GRCh38	Loss	TUBA3FP THAP7-AS1 P2RX6 AIFM3 THAP7 CRKL MIR649 SLC7A4 SNAP29 LOC101928891 LRRC74B P2RX6P LZTR1
esv2763693	Chr.22:20581182 - 21111546 on Build GRCh38	Gain	TUBA3FP TMEM191A THAP7-AS1 SERPIND1 BCRP2 MED15 P2RX6 AIFM3 THAP7 CRKL MIR649 SLC7A4 POM121L4P SNAP29 LOC101928891 PI4KA SMPD4P1 LRRC74B P2RX6P LZTR1
esv3647304	Chr.22:20902577 - 21081487 on Build GRCh38	Loss	TUBA3FP MIR649 SLC7A4 THAP7-AS1 LOC101928891 P2RX6 LRRC74B AIFM3 P2RX6P LZTR1 THAP7 CRKL
nsv588305	Chr.22:20721841 - 21108064 on Build GRCh38	Loss	TUBA3FP THAP7-AS1 SERPIND1 BCRP2 P2RX6 AIFM3 THAP7 CRKL MIR649 SLC7A4 SNAP29 LOC101928891 PI4KA LRRC74B P2RX6P LZTR1
esv2678175	Chr.22:20691629 - 21284480 on Build GRCh38	Deletion	FAM230B TUBA3FP TMEM191A THAP7-AS1 SERPIND1 BCRP2 P2RX6 GGT2 AIFM3 THAP7 POM121L8P CRKL MIR649 SLC7A4 POM121L4P SNAP29 LOC101928891 PI4KA LRRC74B P2RX6P LZTR1
dgv7993n54	Chr.22:20346736 - 21111491 on Build GRCh38	Gain	KLHL22 TMEM191A MED15 USP41 AIFM3 THAP7 LOC101928891 PI4KA LZTR1 TUBA3FP THAP7-AS1 SERPIND1 BCRP2 LOC101927859 ZNF74 P2RX6 CRKL MIR649 SLC7A4 POM121L4P SNAP29 SMPD4P1 LRRC74B P2RX6P SCARF2
nsv834140	Chr.22:20742586 - 20951488 on Build GRCh38	Loss	SNAP29 SERPIND1 PI4KA CRKL
dgv4483n100	Chr.22:20362634 - 21212930 on Build GRCh38	Gain	KLHL22 TMEM191A MED15 USP41 AIFM3 THAP7 LOC101928891 PI4KA LZTR1 FAM230B TUBA3FP THAP7-AS1 SERPIND1 BCRP2 ZNF74 P2RX6 GGT2 CRKL MIR649 SLC7A4 POM121L4P SNAP29 SMPD4P1 LRRC74B P2RX6P SCARF2
nsv1066625	Chr.22:20920683 - 20948518 on Build GRCh38	Gain	CRKL
nsv523162	Chr.22:20389246 - 21108064 on Build GRCh38	Loss	TUBA3FP KLHL22 TMEM191A THAP7-AS1 SERPIND1 BCRP2 ZNF74 MED15 P2RX6 USP41 AIFM3 THAP7 CRKL MIR649 SLC7A4 POM121L4P SNAP29 LOC101928891 PI4KA SMPD4P1 LRRC74B P2RX6P LZTR1 SCARF2

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

activation of MAPKK activity
blood vessel development
JNK cascade
Ras protein signal transduction
heart development
positive regulation of cell proliferation
organ morphogenesis
anterior/posterior pattern specification
intracellular signal transduction
thymus development
parathyroid gland development
cell-cell adhesion
positive regulation of substrate adhesion-dependent cell spreading

Function(s)

signal transducer activity
SH3/SH2 adaptor activity
protein binding
poly(A) RNA binding
cadherin binding involved in cell-cell adhesion