Hs04094791_cn

• Gene Symbol: CRKL
• Assay Reference Genome Location: Chr.22:20932532 on build GRCh38
• Cytoband: 22q11.21

Target Gene Details

• Entrez Gene ID: 1399
• Gene Name: CRK like proto-oncogene, adaptor protein
• Gene Aliases: -
• Location: Chr.22:20917398-20953749 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
CRKL	NM_005207.3			NP_005198.1
	AK292909.1
	BC043500.1			AAH43500.1
	CR456423.1			CAG30309.1
	X59656.1			CAA42199.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3893441	Chr.22:20733858 - 21135629 on Build GRCh38	Gain+Loss	PI4KA LOC101928891 SLC7A4 LZTR1 MIR649 THAP7 P2RX6 AIFM3 SERPIND1 CRKL TUBA3FP P2RX6P SNAP29 LRRC74B THAP7-AS1 BCRP2
nsv1065617	Chr.22:20705383 - 21111546 on Build GRCh38	Gain	PI4KA LOC101928891 SLC7A4 LZTR1 MIR649 THAP7 P2RX6 AIFM3 SERPIND1 CRKL TUBA3FP P2RX6P SNAP29 LRRC74B THAP7-AS1 BCRP2
dgv7994n54	Chr.22:20559470 - 21111491 on Build GRCh38	Gain	MED15 PI4KA TMEM191A LOC101928891 SLC7A4 SMPD4P1 LZTR1 POM121L4P MIR649 THAP7 P2RX6 AIFM3 SERPIND1 CRKL TUBA3FP P2RX6P SNAP29 LRRC74B THAP7-AS1 BCRP2
nsv834141	Chr.22:20859455 - 21051952 on Build GRCh38	Loss	LOC101928891 SLC7A4 LZTR1 MIR649 THAP7 P2RX6 AIFM3 CRKL TUBA3FP P2RX6P SNAP29 LRRC74B THAP7-AS1
esv2763693	Chr.22:20581182 - 21111546 on Build GRCh38	Gain	MED15 PI4KA TMEM191A LOC101928891 SLC7A4 SMPD4P1 LZTR1 POM121L4P MIR649 THAP7 P2RX6 AIFM3 SERPIND1 CRKL TUBA3FP P2RX6P SNAP29 LRRC74B THAP7-AS1 BCRP2
esv3647304	Chr.22:20902577 - 21081487 on Build GRCh38	Loss	AIFM3 CRKL LOC101928891 TUBA3FP SLC7A4 LZTR1 MIR649 THAP7 P2RX6P LRRC74B THAP7-AS1 P2RX6
nsv588305	Chr.22:20721841 - 21108064 on Build GRCh38	Loss	PI4KA LOC101928891 SLC7A4 LZTR1 MIR649 THAP7 P2RX6 AIFM3 SERPIND1 CRKL TUBA3FP P2RX6P SNAP29 LRRC74B THAP7-AS1 BCRP2
esv2678175	Chr.22:20691629 - 21284480 on Build GRCh38	Deletion	PI4KA TMEM191A LOC101928891 SLC7A4 LZTR1 POM121L4P MIR649 THAP7 POM121L8P P2RX6 AIFM3 SERPIND1 FAM230B GGT2 CRKL TUBA3FP P2RX6P SNAP29 LRRC74B THAP7-AS1 BCRP2
dgv7993n54	Chr.22:20346736 - 21111491 on Build GRCh38	Gain	TMEM191A LZTR1 POM121L4P P2RX6 ZNF74 KLHL22 CRKL TUBA3FP SNAP29 LRRC74B THAP7-AS1 MED15 PI4KA LOC101928891 SLC7A4 SMPD4P1 MIR649 SCARF2 THAP7 LOC101927859 AIFM3 SERPIND1 USP41 P2RX6P BCRP2
nsv834140	Chr.22:20742586 - 20951488 on Build GRCh38	Loss	PI4KA SERPIND1 CRKL SNAP29
dgv4483n100	Chr.22:20362634 - 21212930 on Build GRCh38	Gain	TMEM191A LZTR1 POM121L4P P2RX6 ZNF74 KLHL22 FAM230B GGT2 CRKL TUBA3FP SNAP29 LRRC74B THAP7-AS1 MED15 PI4KA LOC101928891 SLC7A4 SMPD4P1 MIR649 SCARF2 THAP7 AIFM3 SERPIND1 USP41 P2RX6P BCRP2
nsv1066625	Chr.22:20920683 - 20948518 on Build GRCh38	Gain	CRKL
dgv4484n100	Chr.22:20928403 - 20948062 on Build GRCh38	Gain	CRKL
nsv523162	Chr.22:20389246 - 21108064 on Build GRCh38	Loss	MED15 PI4KA TMEM191A LOC101928891 SLC7A4 SMPD4P1 LZTR1 POM121L4P MIR649 SCARF2 THAP7 P2RX6 ZNF74 AIFM3 KLHL22 SERPIND1 CRKL TUBA3FP USP41 P2RX6P SNAP29 LRRC74B THAP7-AS1 BCRP2

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

activation of MAPKK activity
blood vessel development
JNK cascade
Ras protein signal transduction
heart development
positive regulation of cell proliferation
organ morphogenesis
anterior/posterior pattern specification
intracellular signal transduction
thymus development
parathyroid gland development
cell-cell adhesion
positive regulation of substrate adhesion-dependent cell spreading

Function(s)

signal transducer activity
SH3/SH2 adaptor activity
protein binding
poly(A) RNA binding
cadherin binding involved in cell-cell adhesion