Hs04489656_cn

• Gene Symbol: STK11
• Assay Reference Genome Location: Chr.19:1210128 on build GRCh38
• Cytoband: 19p13.3

Target Gene Details

• Entrez Gene ID: 6794
• Gene Name: serine/threonine kinase 11
• Gene Aliases: LKB1, PJS, hLKB1
• Location: Chr.19:1205799-1228435 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
STK11	NM_000455.4			NP_000446.1
	XM_005259617.2			XP_005259674.1
	XM_005259618.3			XP_005259675.1
	XM_011528209.1			XP_011526511.1
	AB209553.1			BAD92790.1
	AF035625.1			AAC39527.1
	AF217978.1			AAG17221.1
	AK314858.1
	BC007981.2			AAH07981.1
	BC019334.1			AAH19334.1
	EF644172.1
	KU178339.1
	KU178340.1
	U63333.1			AAB05809.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1058677	Chr.19:1054061 - 1283189 on Build GRCh38	Loss	MIDN EFNA2 CIRBP CBARP GPX4 LOC102725180 SBNO2 STK11 POLR2E CIRBP-AS1 ARHGAP45 C19orf24 ATP5D ABCA7
dgv136n111	Chr.19:1038223 - 1329640 on Build GRCh38	Deletion	MIDN EFNA2 CIRBP CBARP GPX4 LOC102725180 SBNO2 STK11 POLR2E CIRBP-AS1 ARHGAP45 C19orf24 CNN2 ATP5D ABCA7
nsv9662	Chr.19:893394 - 1317740 on Build GRCh38	Gain	MIDN EFNA2 ARID3A RNU6-2 CIRBP CBARP LOC105372235 GPX4 R3HDM4 LOC102725180 SBNO2 STK11 POLR2E RNU6-9 CIRBP-AS1 TMEM259 KISS1R GRIN3B ARHGAP45 C19orf24 CNN2 ATP5D ABCA7 WDR18
nsv470104	Chr.19:1170446 - 1325151 on Build GRCh38	Loss	LOC102725180 SBNO2 MIDN STK11 EFNA2 CIRBP-AS1 C19orf24 CIRBP ATP5D CBARP
nsv1160555	Chr.19:887275 - 1346084 on Build GRCh38	Deletion	MIDN EFNA2 ARID3A RNU6-2 CIRBP LOC105372235 GPX4 R3HDM4 POLR2E MED16 CIRBP-AS1 KISS1R GRIN3B C19orf24 ABCA7 WDR18 CBARP LOC102725180 SBNO2 STK11 RNU6-9 TMEM259 ARHGAP45 CNN2 ATP5D
nsv953941	Chr.19:1205602 - 1322401 on Build GRCh38	Deletion	MIDN STK11 EFNA2 CIRBP-AS1 C19orf24 CIRBP ATP5D CBARP
nsv470103	Chr.19:1086044 - 1325151 on Build GRCh38	Gain	MIDN EFNA2 CIRBP CBARP GPX4 LOC102725180 SBNO2 STK11 POLR2E CIRBP-AS1 ARHGAP45 C19orf24 ATP5D
esv2758743	Chr.19:951641 - 1544934 on Build GRCh38	Gain+Loss	REEP6 MIDN EFNA2 C19orf25 MUM1 ARID3A NDUFS7 RNU6-2 CIRBP LOC105372235 GPX4 POLR2E APC2 CIRBP-AS1 GRIN3B C19orf24 GAMT PCSK4 ABCA7 WDR18 PLK5 ADAMTSL5 CBARP LOC102725180 SBNO2 STK11 TMEM259 ARHGAP45 DAZAP1 CNN2 ATP5D RPS15

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

regulation of cell growth
tissue homeostasis
vasculature development
protein phosphorylation
autophagy
cellular response to DNA damage stimulus
cell cycle arrest
spermatid development
axonogenesis
negative regulation of cell proliferation
response to ionizing radiation
positive regulation of autophagy
establishment of cell polarity
regulation of Wnt signaling pathway
negative regulation of cell growth
positive regulation of transforming growth factor beta receptor signaling pathway
activation of protein kinase activity
TCR signalosome assembly
glucose homeostasis
anoikis
positive thymic T cell selection
protein autophosphorylation
regulation of dendrite morphogenesis
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of axonogenesis
T cell receptor signaling pathway
negative regulation of lipid biosynthetic process
Golgi localization
regulation of protein kinase B signaling
canonical Wnt signaling pathway
negative regulation of epithelial cell proliferation involved in prostate gland development
cellular response to UV-B
positive regulation of protein serine/threonine kinase activity
intrinsic apoptotic signaling pathway by p53 class mediator
dendrite extension
positive regulation of protein localization to nucleus
regulation of signal transduction by p53 class mediator
negative regulation of TORC1 signaling

Function(s)

magnesium ion binding
p53 binding
protein serine/threonine kinase activity
protein binding
ATP binding
LRR domain binding
protein kinase activator activity