Hs04499737_cn

• Gene Symbol: TPTE
• Assay Reference Genome Location: Chr.21:10539580 on build GRCh38
• Cytoband: 21p11.2

Target Gene Details

• Entrez Gene ID: 7179
• Gene Name: transmembrane phosphatase with tensin homology
• Gene Aliases: CT44, PTEN2
• Location: Chr.21:10521514-10606270 on Build GRCh38
• Assay Gene Location: Within Intron 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TPTE	NM_001290224.1			NP_001277153.1
	NM_199259.3			NP_954868.1
	NM_199260.3			NP_954869.1
	NM_199261.3			NP_954870.2
	AF007118.1			AAC34574.1
	AF495908.1			AAQ06674.1
	AK308254.1
	AK314285.1
	AL833345.1
	AY219886.1			AAP45143.1
	AY219887.1			AAP45144.1
	AY219888.1			AAP45145.1
	BC028719.1			AAH28719.1
	DB459772.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv4363n100	Chr.21:10420787 - 10576547 on Build GRCh38	Loss	LOC105378260 TPTE BAGE2
dgv712n67	Chr.21:10449897 - 10648466 on Build GRCh38	Gain	LOC105378260 TPTE BAGE2
esv3445742	Chr.21:10524878 - 10544976 on Build GRCh38	Duplication	TPTE
dgv4364n100	Chr.21:10535770 - 10558343 on Build GRCh38	Loss	TPTE
nsv438312	Chr.21:10501309 - 10555734 on Build GRCh38	Loss	LOC105378260 TPTE
dgv4366n100	Chr.21:10502083 - 10558343 on Build GRCh38	Gain+Loss	LOC105378260 TPTE
dgv7728n54	Chr.21:10416793 - 10813996 on Build GRCh38	Gain	IGHV1OR21-1 LOC105378260 TPTE BAGE2
dgv794e214	Chr.21:10521694 - 10566592 on Build GRCh38	Gain	TPTE
esv2661615	Chr.21:10334870 - 10567118 on Build GRCh38	Deletion	LOC105378260 TPTE BAGE2
nsv428382	Chr.21:10337224 - 10764692 on Build GRCh38	Gain+Loss	IGHV1OR21-1 LOC105378260 TPTE BAGE2
dgv7748n54	Chr.21:10507714 - 10657385 on Build GRCh38	Loss	IGHV1OR21-1 LOC105378260 TPTE
esv32564	Chr.21:10336174 - 10647411 on Build GRCh38	Gain+Loss	LOC105378260 TPTE BAGE2
dgv2465e59	Chr.21:10533078 - 10545076 on Build GRCh38	Duplication	TPTE
nsv9837	Chr.21:10524671 - 10660645 on Build GRCh38	Gain+Loss	IGHV1OR21-1 TPTE
nsv436336	Chr.21:10334792 - 10567767 on Build GRCh38	Deletion	LOC105378260 TPTE BAGE2
dgv4356n100	Chr.21:10448879 - 10643715 on Build GRCh38	Loss	LOC105378260 TPTE BAGE2
dgv4355n100	Chr.21:10338676 - 10775598 on Build GRCh38	Gain	IGHV1OR21-1 LOC105378260 TPTE BAGE2
nsv586977	Chr.21:10515528 - 10599016 on Build GRCh38	Loss	TPTE
nsv1059477	Chr.21:10458823 - 10643715 on Build GRCh38	Gain	LOC105378260 TPTE BAGE2
nsv953331	Chr.21:10427057 - 10739656 on Build GRCh38	Duplication	IGHV1OR21-1 LOC105378260 TPTE BAGE2
nsv962658	Chr.21:10539220 - 10540125 on Build GRCh38	Duplication	TPTE
nsv1062472	Chr.21:10524034 - 10558343 on Build GRCh38	Gain	TPTE
dgv4351n100	Chr.21:10536307 - 10775598 on Build GRCh38	Gain	IGHV1OR21-1 TPTE
dgv7737n54	Chr.21:10526466 - 10751106 on Build GRCh38	Loss	IGHV1OR21-1 TPTE
nsv1059291	Chr.21:10348542 - 10775598 on Build GRCh38	Loss	IGHV1OR21-1 LOC105378260 TPTE BAGE2
nsv1147252	Chr.21:10522357 - 10741958 on Build GRCh38	Duplication	IGHV1OR21-1 TPTE
esv29976	Chr.21:10345209 - 10646524 on Build GRCh38	Gain	LOC105378260 TPTE BAGE2
nsv1124842	Chr.21:10522557 - 10542957 on Build GRCh38	Duplication	TPTE
dgv4353n100	Chr.21:10458894 - 10775598 on Build GRCh38	Loss	IGHV1OR21-1 LOC105378260 TPTE BAGE2
esv3415159	Chr.21:10537178 - 10544476 on Build GRCh38	Duplication	TPTE
dgv4365n100	Chr.21:10504328 - 10558343 on Build GRCh38	Loss	LOC105378260 TPTE
esv1000174	Chr.21:10334703 - 10569121 on Build GRCh38	Deletion	LOC105378260 TPTE BAGE2
nsv437841	Chr.21:10326676 - 10605468 on Build GRCh38	Loss	LOC105378260 TPTE BAGE2
dgv7729n54	Chr.21:10324453 - 10813996 on Build GRCh38	Gain	IGHV1OR21-1 LOC105378260 TPTE BAGE2
nsv512628	Chr.21:10334208 - 10567327 on Build GRCh38	Loss	LOC105378260 TPTE BAGE2
dgv67n17	Chr.21:10539128 - 10595541 on Build GRCh38	Loss	TPTE
esv2763681	Chr.21:10336545 - 10775586 on Build GRCh38	Gain+Loss	IGHV1OR21-1 LOC105378260 TPTE BAGE2
dgv4362n100	Chr.21:10534998 - 10589451 on Build GRCh38	Loss	TPTE
esv2760696	Chr.21:10494350 - 10775586 on Build GRCh38	Gain+Loss	IGHV1OR21-1 LOC105378260 TPTE
esv28756	Chr.21:10324359 - 10814516 on Build GRCh38	Gain+Loss	IGHV1OR21-1 LOC105378260 TPTE BAGE2

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

protein phosphatase

Gene Ontology Categories:

Process(es)

protein dephosphorylation
signal transduction
peptidyl-tyrosine dephosphorylation

Function(s)

protein tyrosine phosphatase activity
protein tyrosine/serine/threonine phosphatase activity