Hs04631458_cn

• Gene Symbol: IL1B
• Assay Reference Genome Location: Chr.2:112834397 on build GRCh38
• Cytoband: 2q14.1

Target Gene Details

• Entrez Gene ID: 3553
• Gene Name: interleukin 1 beta
• Gene Aliases: IL-1, IL1-BETA, IL1F2
• Location: Chr.2:112829758-112836842 on Build GRCh38
• Assay Gene Location: Within Intron 3

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
IL1B	NM_000576.2			NP_000567.1
	XM_017003988.1			XP_016859477.1
	AK313983.1
	BC008678.1			AAH08678.1
	BT007213.1			AAP35877.1
	CR407679.1			CAG28607.1
	K02770.1			AAA36106.1
	M15330.1			AAA59135.1
	M54933.1			AAA59136.1
	X02532.1			CAA26372.1
	X56087.1			CAA39567.1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, non-DGV Variation

Panther Classification:

Molecular Function -

interleukin superfamily

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
activation of MAPK activity
fever generation
response to hypoxia
positive regulation of protein phosphorylation
chronic inflammatory response to antigenic stimulus
positive regulation of T cell mediated immunity
purine nucleobase metabolic process
apoptotic process
inflammatory response
signal transduction
positive regulation of cytosolic calcium ion concentration
cell-cell signaling
embryo implantation
aging
memory
estrogen metabolic process
negative regulation of cell proliferation
glycoprotein metabolic process
response to heat
response to ozone
response to gamma radiation
positive regulation of vascular endothelial growth factor production
positive regulation of gene expression
negative regulation of glucose transport
negative regulation of glutamate secretion
smooth muscle adaptation
cytokine-mediated signaling pathway
pentacyclic triterpenoid metabolic process
hyaluronan biosynthetic process
neutrophil chemotaxis
polyketide metabolic process
ovulation
sequestering of triglyceride
positive regulation of vascular endothelial growth factor receptor signaling pathway
positive regulation of fever generation
lipopolysaccharide-mediated signaling pathway
positive regulation of prostaglandin secretion
response to estradiol
interleukin-1 beta production
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of interferon-gamma production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of immature T cell proliferation in thymus
positive regulation of histone phosphorylation
response to ATP
response to vitamin D
response to L-ascorbic acid
positive regulation of heterotypic cell-cell adhesion
positive regulation of histone acetylation
social behavior
ectopic germ cell programmed cell death
positive regulation of myosin light chain kinase activity
response to stilbenoid
cellular response to drug
response to diuretic
response to statin
wound healing
positive regulation of T cell proliferation
positive regulation of NF-kappaB import into nucleus
positive regulation of apoptotic process
regulation of I-kappaB kinase/NF-kappaB signaling
response to morphine
negative regulation of MAP kinase activity
response to peptide hormone
protein kinase B signaling
positive regulation of JUN kinase activity
positive regulation of chemokine biosynthetic process
positive regulation of interleukin-2 biosynthetic process
positive regulation of interleukin-6 biosynthetic process
positive regulation of nitric oxide biosynthetic process
response to ethanol
negative regulation of neuron differentiation
positive regulation of angiogenesis
negative regulation of lipid metabolic process
positive regulation of mitotic nuclear division
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
negative regulation of insulin receptor signaling pathway
positive regulation of protein export from nucleus
positive regulation of astrocyte differentiation
positive regulation of phagocytosis
regulation of insulin secretion
negative regulation of lipid catabolic process
positive regulation of lipid catabolic process
regulation of nitric-oxide synthase activity
positive regulation of membrane protein ectodomain proteolysis
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
positive regulation of cell division
positive regulation of cell adhesion molecule production
positive regulation of calcidiol 1-monooxygenase activity
negative regulation of adiponectin secretion
positive regulation of ERK1 and ERK2 cascade
monocyte aggregation
cellular response to antibiotic
cellular response to mechanical stimulus
cellular response to organic substance
cellular response to glucose stimulus
cellular response to fatty acid
cellular response to organic cyclic compound
cellular response to methotrexate
response to dexamethasone
positive regulation of monocyte chemotactic protein-1 production
positive regulation of neutrophil chemotaxis
extrinsic apoptotic signaling pathway in absence of ligand
regulation of establishment of endothelial barrier
negative regulation of branching morphogenesis of a nerve
negative regulation of neural precursor cell proliferation
positive regulation of interleukin-6 secretion
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Function(s)

cytokine activity
interleukin-1 receptor binding
protein domain specific binding