Hs04744341_cn

• Gene Symbol: PPARG
• Assay Reference Genome Location: Chr.3:12310989 on build GRCh38
• Cytoband: 3p25.2

Target Gene Details

• Entrez Gene ID: 5468
• Gene Name: peroxisome proliferator activated receptor gamma
• Gene Aliases: CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma
• Location: Chr.3:12287850-12471054 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PPARG	NM_005037.5			NP_005028.4
	NM_138711.3			NP_619725.2
	NM_138712.3			NP_619726.2
	XM_011533841.2			XP_011532143.1
	XM_011533844.1			XP_011532146.1
	AB097931.1			BAD20647.1
	AB107271.1			BAD34540.1
	AB472042.1
	AB565476.1
	AJ563370.1			CAD91389.1
	AK290581.1
	AL523434.3
	BC006811.1			AAH06811.1
	BG323933.1
	BM923992.1
	X90563.1			CAA62152.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1000995	Chr.3:12308425 - 12594756 on Build GRCh38	Gain	MKRN2OS TSEN2 MKRN2 RAF1 PPARG
nsv1147269	Chr.3:11914420 - 12871937 on Build GRCh38	Deletion	CAND2 MKRN2OS TSEN2 TMEM40 MKRN2 RAF1 SNORA7A RPL32 SYN2 TIMP4 PPARG
nsv1112379	Chr.3:11914395 - 12871920 on Build GRCh38	Deletion	CAND2 MKRN2OS TSEN2 TMEM40 MKRN2 RAF1 SNORA7A RPL32 SYN2 TIMP4 PPARG
dgv850e199	Chr.3:11914188 - 12872013 on Build GRCh38	Deletion	CAND2 MKRN2OS TSEN2 TMEM40 MKRN2 RAF1 SNORA7A RPL32 SYN2 TIMP4 PPARG
esv7808	Chr.3:12310301 - 12311049 on Build GRCh38	Loss	PPARG
dgv763e201	Chr.3:11909121 - 12871926 on Build GRCh38	Deletion	CAND2 MKRN2OS TSEN2 TMEM40 MKRN2 RAF1 SNORA7A RPL32 SYN2 TIMP4 PPARG

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

C4 zinc finger nuclear receptor, DNA-binding transcription factor, zinc finger transcription factor, gene-specific transcriptional regulator

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
placenta development
negative regulation of acute inflammatory response
transcription initiation from RNA polymerase II promoter
lipid metabolic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
G-protein coupled receptor signaling pathway
heart development
response to nutrient
regulation of blood pressure
response to cold
response to mechanical stimulus
macrophage derived foam cell differentiation
negative regulation of macrophage derived foam cell differentiation
negative regulation of receptor biosynthetic process
negative regulation of cholesterol storage
negative regulation of sequestering of triglyceride
long-chain fatty acid transport
fatty acid oxidation
monocyte differentiation
negative regulation of cell growth
epithelial cell differentiation
response to caffeine
organ regeneration
response to retinoic acid
cellular response to insulin stimulus
negative regulation of collagen biosynthetic process
response to vitamin A
response to lipid
peroxisome proliferator activated receptor signaling pathway
response to immobilization stress
response to diuretic
glucose homeostasis
response to starvation
regulation of circadian rhythm
lipoprotein transport
steroid hormone mediated signaling pathway
response to estrogen
innate immune response
cell fate commitment
positive regulation of fat cell differentiation
low-density lipoprotein particle receptor biosynthetic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fatty acid oxidation
cell maturation
rhythmic process
negative regulation of smooth muscle cell proliferation
positive regulation of oligodendrocyte differentiation
white fat cell differentiation
positive regulation of sequence-specific DNA binding transcription factor activity
negative regulation of telomerase activity
lipid homeostasis
response to low-density lipoprotein particle
positive regulation of phagocytosis, engulfment
negative regulation of interferon-gamma-mediated signaling pathway
regulation of cholesterol transporter activity
regulation of transcription involved in cell fate commitment
cellular response to retinoic acid
cellular response to vitamin E
cellular response to prostaglandin E stimulus
cellular response to hyperoxia
response to metformin
negative regulation of pancreatic stellate cell proliferation

Function(s)

core promoter sequence-specific DNA binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
prostaglandin receptor activity
protein binding
transcription factor binding
drug binding
zinc ion binding
enzyme binding
protein phosphatase binding
estrogen receptor binding
ligand-dependent nuclear receptor transcription coactivator activity
activating transcription factor binding
identical protein binding
sequence-specific DNA binding
transcription regulatory region DNA binding
retinoid X receptor binding
arachidonic acid binding
alpha-actinin binding