Hs04960108_cn

• Gene Symbol: CRHR2
• Assay Reference Genome Location: Chr.7:30657168 on build GRCh38
• Cytoband: 7p14.3

Target Gene Details

• Entrez Gene ID: 1395
• Gene Name: corticotropin releasing hormone receptor 2
• Gene Aliases: CRF-RB, CRF2, CRFR2, HM-CRF
• Location: Chr.7:30651844-30700103 on Build GRCh38
• Assay Gene Location: Within Intron 11

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
CRHR2	NM_001202475.1			NP_001189404.1
	NM_001202481.1			NP_001189410.1
	NM_001202482.1			NP_001189411.1
	NM_001202483.1			NP_001189412.1
	NM_001883.4			NP_001874.2
	XM_011515127.2			XP_011513429.1
	XM_011515128.2			XP_011513430.1
	XM_011515129.2			XP_011513431.1
	XM_017011751.1			XP_016867240.1
	XM_017011752.1			XP_016867241.1
	AF011406.1			AAB94503.1
	AF019381.1			AAB94562.1
	AK313661.1
	AY449734.1			AAR18078.1
	BC096830.1			AAH96830.1
	EU012439.1
	EU012440.1
	EU012441.1
	EU012442.1
	EU012443.1
	FJ200484.1
	U34587.1			AAA91320.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv6316n100	Chr.7:30609596 - 31145482 on Build GRCh38	Gain	INMT-FAM188B GHRHR CRHR2 AQP1 ADCYAP1R1 FAM188B INMT GARS
nsv830938	Chr.7:30644614 - 30857907 on Build GRCh38	Gain	INMT-FAM188B CRHR2 FAM188B INMT
nsv527038	Chr.7:30617851 - 31122331 on Build GRCh38	Gain	INMT-FAM188B GHRHR CRHR2 AQP1 ADCYAP1R1 FAM188B INMT GARS
esv2761316	Chr.7:30615466 - 31127062 on Build GRCh38	Gain	INMT-FAM188B GHRHR CRHR2 AQP1 ADCYAP1R1 FAM188B INMT GARS
nsv436557	Chr.7:30288062 - 32730902 on Build GRCh38	Deletion	LSM5 GGCT GHRHR CCDC129 AQP1 ZNRF2 GARS MIR550A1 CRHR2 FAM188B ZNRF2P1 NEUROD6 DKFZP586I1420 PDE1C ADCYAP1R1 DPY19L1P1 LINC01176 LOC401320 LOC101928268 INMT-FAM188B AVL9 PPP1R17 NOD1 MIR550B1 LOC100130673 INMT

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

actin filament organization
cell surface receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
protein kinase C-activating G-protein coupled receptor signaling pathway
hormone-mediated signaling pathway
positive regulation of heart rate
positive regulation of gene expression
negative regulation of gene expression
negative regulation of norepinephrine secretion
positive regulation of serotonin secretion
sensory perception of pain
cerebellum development
hypothalamus development
negative regulation of cAMP biosynthetic process
positive regulation of cAMP biosynthetic process
epithelial cell differentiation
positive regulation of interleukin-6 production
negative regulation of epinephrine secretion
positive regulation of stress-activated MAPK cascade
negative regulation of luteinizing hormone secretion
gastric motility
catecholamine biosynthetic process
positive regulation of blood pressure
negative regulation of follicle-stimulating hormone secretion
skeletal muscle tissue growth
positive regulation of NF-kappaB transcription factor activity
long-term synaptic potentiation
negative regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of ERK1 and ERK2 cascade
cellular response to corticotropin-releasing hormone stimulus
cellular response to glucocorticoid stimulus
negative regulation of calcium ion import
negative regulation of feeding behavior
negative regulation of defecation

Function(s)

protein binding
corticotrophin-releasing factor receptor activity
peptide hormone binding
corticotropin-releasing hormone receptor activity