Hs05243123_cn

• Gene Symbol: CBL
• Assay Reference Genome Location: Chr.11:119229315 on build GRCh38
• Cytoband: 11q23.3

Target Gene Details

• Entrez Gene ID: 867
• Gene Name: Cbl proto-oncogene
• Gene Aliases: C-CBL, CBL2, FRA11B, NSLL, RNF55
• Location: Chr.11:119206276-119308149 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
CBL	NM_005188.3			NP_005179.2
	XM_011543057.2			XP_011541359.1
	BC132733.1
	BC136463.1
	BG722940.1
	DB457271.2
	X57110.1			CAA40393.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3627888	Chr.11:119223299 - 119229897 on Build GRCh38	Loss	CBL

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

ligase, metabolite interconversion enzyme

Gene Ontology Categories:

Process(es)

regulation of transcription, DNA-templated
cell surface receptor signaling pathway
epidermal growth factor receptor signaling pathway
transforming growth factor beta receptor signaling pathway
fibroblast growth factor receptor signaling pathway
positive regulation of phosphatidylinositol 3-kinase signaling
protein ubiquitination
negative regulation of epidermal growth factor receptor signaling pathway
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of apoptotic process
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of receptor-mediated endocytosis
cell-cell adhesion

Function(s)

phosphotyrosine binding
transcription factor activity, sequence-specific DNA binding
ubiquitin-protein transferase activity
signal transducer activity
calcium ion binding
protein binding
zinc ion binding
ligase activity
SH3 domain binding
protein kinase binding
ephrin receptor binding
ubiquitin protein ligase activity
cadherin binding involved in cell-cell adhesion