Hs05330062_cn

• Gene Symbol: NRG4
• Assay Reference Genome Location: Chr.15:75988684 on build GRCh38
• Cytoband: 15q24.2

Target Gene Details

• Entrez Gene ID: 145957
• Gene Name: neuregulin 4
• Gene Aliases: HRG4
• Location: Chr.15:75935190-76062997 on Build GRCh38
• Assay Gene Location: Within Intron 9

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NRG4	NM_138573.3			NP_612640.1
	XM_017021937.1			XP_016877426.1
	XM_017021938.1			XP_016877427.1
	XM_017021939.1			XP_016877428.1
	XM_017021940.1			XP_016877429.1
	XM_017021941.1			XP_016877430.1
	XM_017021942.1			XP_016877431.1
	XM_017021943.1			XP_016877432.1
	XM_017021944.1			XP_016877433.1
	XM_017021945.1			XP_016877434.1
	XM_017021946.1			XP_016877435.1
	XM_017021947.1			XP_016877436.1
	XM_017021948.1			XP_016877437.1
	AK307362.1
	AK311204.1
	AK311507.1
	AM392364.1			CAL35829.1
	AM392365.1			CAL35830.1
	BC017568.1			AAH17568.1
	BX538100.1			CAD98015.1
	CR749519.1			CAH18333.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2749895	Chr.15:75415580 - 76472296 on Build GRCh38	Deletion	DNM1P35 CSPG4 SCAPER LOC441728 TYRO3P ODF3L1 NRG4 SNX33 ETFA SNUPN LOC101929439 FBXO22 LOC107984799 UBE2Q2 MIR4313 FBXO22-AS1 TMEM266 ISL2 SIN3A IMP3 PTPN9
nsv569998	Chr.15:75940264 - 76258597 on Build GRCh38	Gain	LOC101929439 NRG4 TMEM266 ETFA
esv3636933	Chr.15:75908231 - 76025938 on Build GRCh38	Gain	FBXO22 FBXO22-AS1 NRG4
nsv518261	Chr.15:75982171 - 75991601 on Build GRCh38	Loss	NRG4
esv2749898	Chr.15:75764003 - 77933523 on Build GRCh38	Deletion	LINGO1 PEAK1 SCAPER LOC441728 LINC00597 TYRO3P LOC645752 NRG4 LINGO1-AS1 MIR3713 ETFA LINGO1-AS2 LOC101929439 FBXO22 PSTPIP1 HMG20A TSPAN3 UBE2Q2 FBXO22-AS1 TMEM266 LOC101929457 ISL2 RCN2
nsv518214	Chr.15:75968089 - 75991601 on Build GRCh38	Loss	NRG4
dgv2622n100	Chr.15:75904333 - 76022201 on Build GRCh38	Gain	FBXO22 FBXO22-AS1 NRG4

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

growth factor

Gene Ontology Categories:

Process(es)

MAPK cascade
regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
intracellular signal transduction
ERBB2 signaling pathway
positive regulation of GTPase activity
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
animal organ development
regulation of cell motility

Function(s)

protein tyrosine kinase activity
Ras guanyl-nucleotide exchange factor activity
receptor binding
protein binding
growth factor activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity