Hs05334424_cn

• Gene Symbol: FBXO22
• Assay Reference Genome Location: Chr.15:75936182 on build GRCh38
• Cytoband: 15q24.2

Target Gene Details

• Entrez Gene ID: 26263
• Gene Name: F-box protein 22
• Gene Aliases: FBX22, FISTC1
• Location: Chr.15:75903859-75937513 on Build GRCh38
• Assay Gene Location: Within Exon 8

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
FBXO22	XM_011521447.2	8	4397	XP_011519749.1

Target Gene Details

• Entrez Gene ID: 145957
• Gene Name: neuregulin 4
• Gene Aliases: HRG4
• Location: Chr.15:75935190-76062997 on Build GRCh38
• Assay Gene Location: Within Exon 14

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NRG4	XM_017021937.1	12	1324	XP_016877426.1
	XM_017021938.1	11	3531	XP_016877427.1
	XM_017021939.1	11	1093	XP_016877428.1
	XM_017021940.1	10	3869	XP_016877429.1
	XM_017021941.1	8	832	XP_016877430.1
	XM_017021942.1	8	850	XP_016877431.1
	XM_017021943.1	8	923	XP_016877432.1
	XM_017021944.1	9	3745	XP_016877433.1
	XM_017021946.1	10	3820	XP_016877435.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2749895	Chr.15:75415580 - 76472296 on Build GRCh38	Deletion	ODF3L1 FBXO22 LOC107984799 ISL2 DNM1P35 FBXO22-AS1 CSPG4 SCAPER MIR4313 SIN3A SNX33 TMEM266 UBE2Q2 PTPN9 LOC101929439 ETFA NRG4 LOC441728 SNUPN IMP3 TYRO3P
nsv1044733	Chr.15:75828583 - 75936539 on Build GRCh38	Loss	FBXO22 NRG4 FBXO22-AS1 UBE2Q2
esv3636933	Chr.15:75908231 - 76025938 on Build GRCh38	Gain	FBXO22 NRG4 FBXO22-AS1
esv2749898	Chr.15:75764003 - 77933523 on Build GRCh38	Deletion	FBXO22 PSTPIP1 LINGO1 ISL2 FBXO22-AS1 PEAK1 SCAPER TSPAN3 RCN2 MIR3713 LOC101929457 LINC00597 LOC645752 TMEM266 UBE2Q2 LOC101929439 ETFA NRG4 HMG20A LINGO1-AS1 LOC441728 LINGO1-AS2 TYRO3P
dgv2622n100	Chr.15:75904333 - 76022201 on Build GRCh38	Gain	FBXO22 NRG4 FBXO22-AS1

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

growth factor

Gene Ontology Categories:

Process(es)

protein polyubiquitination
cellular protein modification process
ubiquitin-dependent protein catabolic process
nucleocytoplasmic transport
cellular response to starvation
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of skeletal muscle fiber development
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
MAPK cascade
regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
intracellular signal transduction
ERBB2 signaling pathway
positive regulation of GTPase activity
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
animal organ development
regulation of cell motility

Function(s)

ubiquitin-protein transferase activity
protein tyrosine kinase activity
Ras guanyl-nucleotide exchange factor activity
receptor binding
protein binding
growth factor activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity